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A meta-analysis comparing the efficacy and safety of different modes of administration of cream in the treatment of otomycosis

Published online by Cambridge University Press:  13 May 2024

Lei Fan Open the ORCID record for Lei Fan [Opens in a new window] ,
Xue-Meng Xu ,
Bi-Yao Liu ,
Jing Huang  and
Da-Zhong Yan
Lei Fan
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College & School of Clinical Medicine, North Sichuan Medical College, Nanchong, China
Xue-Meng Xu
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College & School of Clinical Medicine, North Sichuan Medical College, Nanchong, China
Bi-Yao Liu
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College & School of Clinical Medicine, North Sichuan Medical College, Nanchong, China
Jing Huang
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College & School of Clinical Medicine, North Sichuan Medical College, Nanchong, China
Da-Zhong Yan*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
*
Corresponding author: Da-Zhong Yan; Email: [email protected]
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Abstract

Objective

To assess the efficacy and safety of two different modes of administration, external ear canal filling and smearing, in the treatment of otomycosis.

Methods

A computerised search of relevant published studies in the China National Knowledge Infrastructure, China Biology Medicine, Web of Science, PubMed, Embase and Cochrane Library databases that include randomised controlled trials or clinically controlled trials on the same drug in different modes of administration for the treatment of otomycosis.

Results

Seven studies with 934 patients were included. The filled group had a higher clinical efficacy (relative risk = 1.18, 95 per cent confidence interval (CI) 1.12–1.24, p < 0.0001) and a lower recurrence rate (relative risk = 0.29, 95 per cent CI 0.18–0.47, p < 0.0001) compared with the smear group, and there was no significant difference in the adverse effects (relative risk = 0.61, 95 per cent CI 0.34–1.12, p = 0.11).

Conclusion

Current evidence suggests that the efficacy of the delivery modality of the external auditory canal filling treatment is significantly better than external auditory canal smearing.

Keywords

treatment outcomeotomycosismeta-analysis
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 11 , November 2024 , pp. 1073 - 1080
Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Da-Zhong Yan takes responsibility for the integrity of the content of the paper

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