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Medical therapy of rhinosporidiosis with dapsone

Published online by Cambridge University Press:  29 June 2007

Anand Job ,
Sarada Venkateswaran ,
Minnie Mathan ,
Hemalatha Krishnaswami  and
Rajagopal Raman
Anand Job
Affiliation:
From the Departments of Otorhinolaryngology, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India.
Sarada Venkateswaran
Affiliation:
From the Departments of Wellcome Research Unit, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India.
Minnie Mathan
Affiliation:
From the Departments of Wellcome Research Unit, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India.
Hemalatha Krishnaswami
Affiliation:
From the Departments of Pathology, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India.
Rajagopal Raman*
Affiliation:
From the Departments of Otorhinolaryngology, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India.
*
Dr R. Raman, Professor and Head of the Department Otorhinolaryngology, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India.
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Abstract

Clinical, histopathological and ultrastmctural studies in three cases of rhinosporidiosis show complete remission of infection within one year of therapy with dapsone. Light and electron microscope studies confirmed arrest of the maturation of the spores and accentuated granulomatous response with fibrosis following dapsone therapy.

Keywords

RhinosporidiosisDapsoneElectron microscopy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 9 , September 1993 , pp. 809 - 812
Copyright
Copyright © JLO (1984) Limited 1993

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References

Bhanu, T. S. (1980) New drug regime for rhinosporidiosis. Indian Journal of Otolaryngology 32: 96–97.CrossRefGoogle Scholar
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Kameswaran, S. (1975) ENT Diseases in a Tropical Environment, 1st Edition., Higginbothams Private Ltd, Madras pp. 53–70.Google Scholar
Nair, K. K. (1979) Clinical trial of diaminodiphenylsulfone (DDS) in nasal and nasopharyngeal rhinosporidiosis. Laryngoscope 89: 291–295.CrossRefGoogle ScholarPubMed