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Mast cells positive for cluster of differentiation 117 protein: are they players or conductor in the orchestra of cholesteatoma?

Published online by Cambridge University Press:  15 June 2012

A O Calli ,
A Sari ,
F Cakalagaoglu ,
A A Altinboga ,
C Calli  and
S Oncel
A O Calli*
Affiliation:
Department of Pathology, Izmir Training and Research Hospital, Turkey
A Sari
Affiliation:
Department of Pathology, Izmir Training and Research Hospital, Turkey
F Cakalagaoglu
Affiliation:
Department of Pathology, Izmir Training and Research Hospital, Turkey
A A Altinboga
Affiliation:
Department of Pathology, Izmir Training and Research Hospital, Turkey
C Calli
Affiliation:
Department of Head and Neck Surgery, Izmir Training and Research Hospital, Turkey
S Oncel
Affiliation:
Department of Head and Neck Surgery, Izmir Training and Research Hospital, Turkey
*
Address for correspondence: Dr Aylin Orgen Calli, Izmir Training and Research Hospital, Department of Pathology, Yesilyurt, Izmir 35290, Turkey Fax: +90 232 2434343 E-mail: [email protected]
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Abstract

Background:

The pathogenesis of cholesteatoma remains unclear, despite several theories. Alterations in the density of mast cells positive for cluster of differentiation 117 protein (also known as CD117) can be critical to cholesteatoma formation, due to the effect on keratinocyte growth factor production. This study aimed to investigate the potential role of these mast cells in cholesteatoma pathogenesis.

Methods:

The number and density of mast cells positive for cluster of differentiation 117 protein were immunohistochemically analysed in 52 patients: 22 with chronic otitis media alone (group one), 25 with chronic otitis media with cholesteatoma (group two) and five controls.

Results:

The number of these mast cells was much higher in group two (in cholesteatoma matrix tissue) than in group one (in chronic otitis media granulation tissue) or the controls (in normal post-auricular skin). The density of these mast cells was significantly greater in group two than in group one or the controls (p < 0.05). The number and density of these mast cells was much greater in group one than in controls (p < 0.01).

Conclusion:

Mast cells positive for cluster of differentiation 117 protein could play a role in cholesteatoma formation. Further investigation of the role of these mast cells in cholesteatoma may suggest new ways of addressing this disorder, and may enable the development of targeted treatments.

Keywords

Mast CellCD117CholesteatomaImmunohistochemistryPathogenesis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 8 , August 2012 , pp. 775 - 779
Copyright
Copyright © JLO (1984) Limited 2012

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