Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-28T00:14:11.810Z Has data issue: false hasContentIssue false
  • English
  • Français

Malignant melanoma of nasal cavity and paranasal sinuses: report of 24 patients and literature review

Published online by Cambridge University Press:  21 January 2011

N Clifton ,
L Harrison ,
P J Bradley  and
N S Jones
N Clifton*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Queen's Medical Centre Campus, Nottingham, UK
L Harrison
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Kings Mill Hospital, Sutton in Ashfield, UK
P J Bradley
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Queen's Medical Centre Campus, Nottingham, UK
N S Jones
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Queen's Medical Centre Campus, Nottingham, UK
*
Address for correspondence: Mr Nicholas Clifton, Tan-Y-Bryn, Fore Street, Holbeton, Plymouth PL8 1NA, UK E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To report our experience of the management of patients with primary sinonasal malignant melanoma, and to review the relevant medical literature.

Method:

Retrospective review examining treatment and outcomes.

Results:

Twenty-four patients were treated between 1982 and 2007. The mean age at presentation was 67.5 years. The overall five-year survival was 30 per cent; mean survival was three years and eight months.

Conclusion:

Sinonasal malignant melanoma is associated with a poor outcome, and survival statistics have not improved over the last 40 years. Treatment should include radical surgery wherever possible. Local recurrence is common; radiotherapy may help control this but does not appear to affect overall survival. The limited evidence available suggests that endoscopic removal of sinonasal malignant melanoma is as effective as other local surgical means, but that craniofacial resection remains the ‘gold standard’ for tumours that contact or traverse the skull base. Novel biological treatments are emerging and hold promise for the future.

Keywords

Nasal CavityParanasal SinusesMelanomaPathologySurgery
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 5 , May 2011 , pp. 479 - 485
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Lund, VJ, Howard, DJ, Wei, WI. Endoscopic resection of malignant tumors of the nose and sinuses. Am J Rhinol 2007;21:89–94CrossRefGoogle Scholar
2Thompson, LD, Wieneke, JA, Miettinen, M. Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 2003;27:594–611CrossRefGoogle ScholarPubMed
3Freedman, HM, De Santo, LW, Devine, KD, Weiland, LH. Malignant melanoma of the nasal cavity and paranasal sinuses. Arch Otolaryngol 1973;97:322–5CrossRefGoogle ScholarPubMed
4Iversen, K, Robins, RE. Mucosal malignant melanomas. Am J Surg 1980;139:660–4CrossRefGoogle ScholarPubMed
5Manolidis, S, Donald, PJ. Malignant mucosal melanoma of the head and neck: review of the literature and report of 14 patients. Cancer 1997;80:1373–863.0.CO;2-G>CrossRefGoogle ScholarPubMed
6Chiu, NT, Weinstock, MA. Melanoma of oronasal mucosa: population-based analysis of occurrence and mortality. Arch Otolaryngol Head Neck Surg 1996;122:985–8CrossRefGoogle ScholarPubMed
7Chang, AE, Karnell, LH, Menck, HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664–783.0.CO;2-G>CrossRefGoogle ScholarPubMed
8Kingdom, TT, Kaplan, MJ. Mucosal melanoma of the nasal cavity and paranasal sinuses. Head Neck 1995;17:184–9CrossRefGoogle ScholarPubMed
9Thompson, AC, Morgan, DA, Bradley, PJ. Malignant melanoma of the nasal cavity and paranasal sinuses. Clin Otolaryngol 1993;18:34–6CrossRefGoogle ScholarPubMed
10Pandey, P, Mathew, A, Iype, EM, Sebastian, P, Abraham, EK, Nair, KM. Primary malignant mucosal melanoma of the head and neck region: pooled analysis of 60 published cases from India and review of the literature. Eur J Cancer Prev 2002;11:3–10CrossRefGoogle Scholar
11Lentsch, EJ, Myers, JN. Melanoma of the head and neck: current concepts in diagnosis and management. Laryngoscope 2001;111:1209–22CrossRefGoogle ScholarPubMed
12Lund, VJ. Malignant melanoma of the nasal cavity and paranasal sinuses. Ear Nose Throat J 1993;72:285–90CrossRefGoogle ScholarPubMed
13Dauer, EH, Lewis, JE, Rohlinger, AL, Weaver, AL, Olsen, KD. Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg 2008;138:347–52CrossRefGoogle ScholarPubMed
14Mangararo, AM, Hammond, HL, Dalton, MJ, Williams, TP. Oral melanoma: case report and a review of the literature. Oral Surg Oral Med Oral Radiol Endod 1995;80:670–6CrossRefGoogle Scholar
15Brandwein, MS, Rothstein, A, Lawson, W, Bodian, C, Urken, ML. Sinonasal melanoma: a clinicopathologic study of 25 cases and literature metanalysis. Arch Otolaryngol Head Neck Surg 1997;123:290–6CrossRefGoogle Scholar
16Holmstrom, M, Lund, VJ. Malignant melanoma of the head and neck. Arch Otolaryngol Head Neck Surg 1989;115:1096–9Google Scholar
17Rivera, RS, Nagatsuka, H, Gunduz, M, Cengiz, B, Gunduz, E, Siar, C et al. C-Kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 2008;452:27–32CrossRefGoogle ScholarPubMed
18Huang, SF, Liao, CT, Kan, CR, Chen, IH. Primary mucosal melanoma of the nasal cavity and paranasal sinuses: 12 years of experience. J Otolaryngol 2007;36:124–9CrossRefGoogle ScholarPubMed
19Bridger, AG, Smee, D, Baldwin, MA, Kwok, B, Bridger, GP. Experience with mucosal melanoma of the nose and paranasal sinuses. A N Z J Surg 2005;75:192–7CrossRefGoogle ScholarPubMed
20Rinaldo, A, Shaha, AR, Patel, SG, Ferlito, A. Primary mucosal melanoma of the nasal cavity and paranasal sinuses. Acta Otolaryngol 2001;121:979–82CrossRefGoogle ScholarPubMed
21Gorres, GW, Stoeckli, SJ, von Schulthess, GK, Steinert, HC. FDG PET for mucosal malignant melanoma of the head and neck. Laryngoscope 2002;112:381–5CrossRefGoogle Scholar
22Morris, LG, Wen, YH, Nonaka, D, DeLacure, MD, Kutler, DI, Huan, Y et al. PNL2 melanocytic marker in immunohistochemical evaluation of primary mucosal melanoma of the head and neck. Head Neck 2008;30:771–5CrossRefGoogle ScholarPubMed
23Billings, KR, Wang, MB, Sercarz, JA, Fu, YS. Clinical and pathological distinction between primary and metastatic mucosal melanoma of the head and neck. Otolaryngol Head Neck Surg 1995;112:700–6CrossRefGoogle ScholarPubMed
24Prasad, ML, Patel, S, Hoshaw-Woodard, S, Escrig, M, Shah, JP, Huvos, AG et al. Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. Am J Surg Path 2002;26:883–92CrossRefGoogle ScholarPubMed
25Patel, SG, Prasad, ML, Escrig, M, Singh, B, Shaha, AR, Kraus, DH et al. Primary mucosal malignant melanoma of the head and neck. Head Neck 2002;24:2247–57CrossRefGoogle ScholarPubMed
26Cuevas, E, Jones, DB, Wright, DH. Immunohistochemical detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J Pathol 1993;169:477–8CrossRefGoogle ScholarPubMed
27Kim, DK, Kim, DW, Kim, SW, Kim, DY, Lee, CH, Rhee, CS. Ki67 antigen as a predictive factor for prognosis of sinonasal mucosal melanoma. Clin Exp Otorhinolaryngol 2008;1:206–10CrossRefGoogle ScholarPubMed
28Patel, S, Shah, JP. Part 2, Head and neck sites. In: Edge, SB, Byrd, DR, Carducci, MA, Compton, CA, eds. AJCC Cancer Staging Manual, 7th edn.New York: Springer, 2009Google Scholar
29Ballantyne, AJ. Malignant melanoma of the skin of the head and neck. An analysis of 405 cases. Am J Surg 1970;120:425–31CrossRefGoogle ScholarPubMed
30Prasad, ML, Patel, SG, Huvos, AG, Shah, JP, Busam, KJ. Primary mucosal melanoma of the head and neck: a proposal for microstaging localised, stage I (lymph node-negative) tumours. Cancer 2004;100:1657–64CrossRefGoogle Scholar
31Prasad, ML, Busam, KJ, Patel, SG, Hoshaw-Woodward, S, Shah, JP, Huvos, AG. Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 2003;127:997–1002CrossRefGoogle ScholarPubMed
32Lee, SP, Shimizu, KT, Tran, LM, Juillard, G, Calcaterra, TC. Mucosal melanoma of the head and neck: the impact of local control on survival. Laryngoscope 1994;104:121–6CrossRefGoogle ScholarPubMed
33Penel, N, Mallet, Y, Mirabel, X, Van, JT, Lefebvre, JL. Primary mucosal melanoma of head and neck: prognostic value of clear margins. Laryngoscope 2006;116:993–5CrossRefGoogle ScholarPubMed
34Owens, JM, Roberts, DB, Myers, JN. The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Arch Otolaryngol Head Neck Surg 2003;129:864–8CrossRefGoogle ScholarPubMed
35Lund, VJ, Howard, DJ, Harding, L, Wei, WI. Management options and survival in malignant melanoma of the sinonasal mucosa. Laryngoscope 1999;109:208–11CrossRefGoogle ScholarPubMed
36Wada, H, Nemoto, K, Ogawa, Y, Hareyama, M, Yoshida, H, Takamura, A et al. A multi-institute retrospective analysis of external beam radiotherapy for mucosal melanoma of the head and neck in northern Japan. Int J Oncol Biol Phys 2004;59:495–500CrossRefGoogle Scholar
37Teman, S, Mamelle, G, Marandas, P, Wibault, P, Avril, M-F, Janot, F et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 2005;103:313–19CrossRefGoogle Scholar
38Nandapalan, V, Roland, NJ, Helliwell, TR, Williams, EM, Hamilton, JW, Jones, AS. Mucosal melanoma of the head and neck. Clin Otolaryngol Allied Sci 1998;23:107–16CrossRefGoogle ScholarPubMed
39Krengli, M, Masini, L, Kaanders, JH, Maingon, P, Oei, SB, Zouhair, A et al. Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study. Int J Radiat Oncol Biol Phys 2006;75:751–9CrossRefGoogle Scholar
40Nicolai, P, Battaglia, P, Bignami, M, Villaret, AB, Delù, G, Kharais, T et al. Endoscopic surgery for malignant tumours of the sinonasal tract and adjacent skull base: a 10-year experience. Am J Rhinol 2008;22:308–16CrossRefGoogle Scholar
41Ganly, I, Patel, SG, Singh, B, Kraus, DH, Bridger, PG, Cantu, G et al. Craniofacial resection for malignant melanoma of the skull base: report of an international collaborative study. Arch Otolaryngol Head Neck Surg 2006;132:73–8CrossRefGoogle ScholarPubMed
42Burns, WR, Frankel, TL, Hinrichs, CS, Zheng, Z, Xu, H, Feldman, S et al. A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas. Cancer Res 2010;15:3027–33CrossRefGoogle Scholar
43Halama, N, Zoernig, I, Jaeger, D. Advanced malignant melanoma: immunologic and multimodal therapeutic strategies. J Oncol 2010, 2010689893.Epub 2010 Mar 9CrossRefGoogle ScholarPubMed
44Eustace, AJ, Mahgoub, T, Tryfonopoulos, D, O'Donovan, N, Crown, J. Prospects for non-immunological molecular therapeutics in melanoma. J BUON 2010;15:9–18Google ScholarPubMed