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Malignant glomus tumour of larynx: first case report and literature review

Published online by Cambridge University Press:  14 May 2012

N Aslam ,
Z-U-S Qazi ,
A H Ahmad  and
R U Khan
N Aslam
Affiliation:
Department of ENT, Head and Neck Surgery, Federal Post Graduate Medical Institute, Shaikh Zayed Hospital, Lahore, Pakistan
Z-U-S Qazi*
Affiliation:
Department of ENT, Head and Neck Surgery, Federal Post Graduate Medical Institute, Shaikh Zayed Hospital, Lahore, Pakistan
A H Ahmad
Affiliation:
Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan
R U Khan
Affiliation:
Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan
*
Address for correspondence: Dr Zia-us-Salam Qazi, 750-B, Street no 4, PCSIR-Phase II, Opposite Shokat Khanum Cancer Hospital and Research Centre, Lahore, Pakistan E-mail: [email protected]
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Abstract

Objective:

We describe the first reported case of a malignant glomus tumour of the larynx.

Method:

Case report and review of the world literature concerning malignant glomus tumours.

Results:

A 37-year-old man presented with progressive hoarseness and dyspnoea. A smooth, right-sided laryngeal mass was found on flexible nasolaryngoscopy. Initial biopsy of this lesion was reported as a true ‘glomus tumour’, which is a benign lesion. Wide local excision was performed. The final histology of this specimen showed it to be a ‘malignant glomus tumour’. Immunohistochemistry was positive for smooth muscle actin, collagen type IV, vimentin and cluster of differentiation 34 glycoprotein. Total laryngectomy was then performed as a definitive curative procedure.

Conclusion:

Glomus tumour is rarely found in visceral locations. This tumour and its malignant counterpart are rare differential diagnoses of laryngeal masses.

Keywords

Glomus TumourGlomangiosarcomaNeoplasmsMalignantLarynx
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 7 , July 2012 , pp. 743 - 746
Copyright
Copyright © JLO (1984) Limited 2012

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