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Long-term results of gentamicin inner ear perfusion in Ménière’s disease

Published online by Cambridge University Press:  16 March 2006

R. Suryanarayanan
Affiliation:
Department of Otolaryngology and Leicester Balance Centre, Leicester Royal Infirmary, Leicester, UK.
J.A. Cook
Affiliation:
Department of Otolaryngology and Leicester Balance Centre, Leicester Royal Infirmary, Leicester, UK.

Abstract

Chemical perfusion of the inner ear is an increasingly popular treatment for Ménière’s disease. The authors report on the long-term results of 22 patients treated with gentamicin delivered via a round window micro-catheter. Patients with Ménière’s disease underwent continuous, low dose (10 mg/ml) gentamicin infusion at 5 microlitre per hour for 10 days, through a micro-catheter placed into the round window niche. Vertigo was controlled in 95 per cent, whilst preserving hearing in 77 per cent. Hearing improved in three patients. Three patients with pre-operative serviceable hearing (PTA < 50 db) demonstrated reduced hearing; two patients with pre-operative non-serviceable hearing developed a dead ear. Tinnitus and aural fullness remained unchanged or improved in 86 per cent and 68 per cent respectively. Long-term vertigo control can be achieved using low dose gentamicin, whilst preserving hearing and vestibular function in the majority of patients. This procedure appears to stabilize the vestibular function, enhancing the chance of effective vestibular rehabilitation.

Type
Research Article
Copyright
© 2004 Royal Society of Medicine Press

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