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Levels of substance P and IgE decapeptide in nasal polyp fluid and matching sera: a preliminary study

Published online by Cambridge University Press:  29 June 2007

A. Drake-Lee ,
V. Jones ,
I. Lewin ,
S. Nayyar ,
A. Wells  and
D. Stanworth
A. Drake-Lee*
Affiliation:
Department of Otolaryngology, Queen Elizabeth Hospital, Birmingham, UK.
V. Jones
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
I. Lewin
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
S. Nayyar
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
A. Wells
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
D. Stanworth
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
*
Address for correspondence: Mr A. Drake-Lee, Department of Otolaryngology, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH. Fax: 0121 627 2291
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Abstract

Sixteen unselected patients with nasal polyps had the levels of substance P and IgE decapeptide measured by ELISA in the oedema fluids and their matched sera. All 16 samples had low levels of substance P in their sera and had high level of substance P in eight samples of nasal polyp oedema. There was a considerable variation in the values of IgE decapeptide found in the sera but 14 polyp oedema fluids had high levels of IgE decapeptide. This study supports the idea that there is a linkage between the cellular and neurovascular responses. High levels of IgE decapeptide suggest that mast cell reactions occur in the majority of cases and that IgE may be implicated in the process of mast cell degranulation.

Keywords

Nasal polypsSubstance PIgE
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 3 , March 1996 , pp. 225 - 227
Copyright
Copyright © JLO (1984) Limited 1996

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