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Larynx preservation after initial non-cisplatin containing combination chemotherapy plus radiotherapy, as opposed to surgical intervention with or without radiotherapy in previously untreated advanced head and neck cancer: final analysis after 12 years follow-up

Published online by Cambridge University Press:  29 June 2007

L. A. Price ,
H. J. Shaw  and
Bridget T. Hill
L. A. Price
Affiliation:
111 Harley Street, London W1N 1DG, UK.
H. J. Shaw
Affiliation:
Chairman (Retired), Head and Neck Unit, Royal Marsden Hospital, London SW3 6JJ, UK
Bridget T. Hill*
Affiliation:
Cellular Chemotherapy Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, UK.
*
Dr B. T. Hill, Cellular Chemotherapy Laboratory, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln's Inn Fields, London WC2A 3PX.
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Abstract

After a median follow-up of 12 years, median overall survival of 73 patients with advanced squamous cell carcinoma of the larynx was 65 months. The 61 per cent of patients responding to two courses of initial schedule A combination chemotherapy, not including cisplatin, and the 81 per cent of patients achieving a final complete remission after definitive local therapy, had median overall survival figures of 95 and 97 months respectively. Overall survival and relapse-free survival in 51 patients treated with radiotherapy only with larynx preservation, were not significantly different from the 21 patients who completed their surgery with pre- or postoperative radiotherapy: median overall figures were 71 versus 65 months. These data add weight to our proposal that use of initial combination chemotherapy followed by radiotherapy may eliminate the need for radical surgery, so preserving the larynx in patients with advanced disease, and provides evidence of some long-term benefit with 32 per cent of this entire group surviving 12 years.

Keywords

Laryngeal neoplasmsCarcinoma, squamous cellLaryngectomyRadiotherapyAntineoplastic agents, combined
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 3 , March 1993 , pp. 211 - 216
Copyright
Copyright © JLO (1984) Limited 1993

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