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Laryngeal sensory neuropathy in patients with diabetes mellitus

Published online by Cambridge University Press:  22 July 2014

A L Hamdan ,
A Dowli ,
R Barazi ,
J Jabbour  and
S Azar
A L Hamdan
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, American University of Beirut Medical Center, New York, USA
A Dowli
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, American University of Beirut Medical Center, New York, USA
R Barazi
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, American University of Beirut Medical Center, New York, USA
J Jabbour
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, American University of Beirut Medical Center, New York, USA
S Azar*
Affiliation:
Internal Medicine Department, American University of Beirut Medical Center, New York, USA
*
Address for correspondence: Dr S Azar, Department of Internal Medicine, American University of Beirut, 3 Dag Hammarskjold Plaza, 8th Floor, NY 10017, USA Fax: +00 (0)961 1 350000 E-mail: [email protected]
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Abstract

Objective:

To determine the prevalence of laryngeal sensory neuropathy in patients with type 2 diabetes mellitus.

Methods:

A cross-sectional study was performed, comprising 50 patients diagnosed with type 2 diabetes mellitus and 36 healthy controls. In the diabetic group, glycaemic control level, disease duration and presence of neuropathy were assessed. Participants were diagnosed with laryngeal sensory neuropathy if they had a cough, globus pharyngeus or throat clearing lasting for more than six weeks, in the absence of laryngopharyngeal reflux disease, allergies, asthma, angiotensin-converting enzyme inhibitor intake or psychogenic disorders.

Results:

In the diabetic group, the mean age ± standard deviation was 44.66 ± 10.07 years. Sixty per cent of patients were male, 42 per cent had had diabetes for more than five years and 52 per cent had average to poor glycaemic control. The prevalence of laryngeal sensory neuropathy was 42 per cent in the diabetic group, compared with 13.9 per cent in controls; this difference was statistically significant (p = 0.005). There was no association between the prevalence of laryngeal sensory neuropathy and glycaemic control level, disease duration or presence of neuropathy.

Conclusion:

Laryngeal sensory neuropathy is more common in patients with type 2 diabetes mellitus than in controls.

Keywords

Diabetes Mellitus, Type 2CoughPharyngeal DiseasesLaryngeal Nerves
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 8 , August 2014 , pp. 725 - 729
Copyright
Copyright © JLO (1984) Limited 2014 

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References

1National Diabetes Statistics, 2011. National Diabetes Information Clearinghouse. In: http://diabetes.niddk.nih.gov/Dm/PUBS/statistics [6 May 2014]Google Scholar
2National Eye Institute. Diabetic Eye Disease FAQ: Prevention and Treatment. In: http://www.nei.nih.gov/diabetes/content/english/faq2.asp [6 May 2014]Google Scholar
3Haffner, SM, D'Agostino, R Jr, Mykkänen, L, Tracy, R, Howard, B, Rewers, M et al. Insulin sensitivity in subjects with type 2 diabetes: relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care 1999;22:562–8Google Scholar
4Jamali, R, Mohseni, S. Hypoglycaemia causes degeneration of large myelinated nerve fibres in the vagus nerve of insulin-treated diabetic BB/Wor rats. Acta Neuropathol 2005;109:198–206Google Scholar
5Lazzaroni, F, Laffi, GL, Galuppi, V, Scorolli, L. Paralysis of oculomotor nerves in diabetes mellitus. A retrospective study of 44 cases [in French]. Rev Neurol (Paris) 1993;149:571–3Google Scholar
6Eshbaugh, CG, Siatkowski, RM, Smith, JL, Kline, LB. Simultaneous, multiple cranial neuropathies in diabetes mellitus. J Neuroophthalmol 1995;15:219–24Google Scholar
7Semiz, S, Fisenk, F, Akcurin, S, Bircan, I. Temporary multiple cranial nerve palsies in a patient with type 1 diabetes mellitus. Diabetes Metab 2002;28:413–6Google Scholar
8Huang, BK, Monu, JU, Doumanian, J. Diabetic myopathy: MRI patterns and current trends. AJR Am J Roentgenol 2010;195:198–204Google Scholar
9Tajiri, Y, Kato, T, Nakayama, H, Yamada, K. Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors. Metab Syndr Relat Disord 2010;8:137–42Google Scholar
10Wong, AD, Best, JA, Shapiro, RD. Diabetic polyneuropathy involving the maxillofacial region: a case report. J Oral Maxillofac Surg 2002;60:935–8Google Scholar
11Vinik, AI, Park, TS, Stansberry, KB, Pittenger, GL. Diabetic neuropathies. Diabetologia 2000;43:957–73Google Scholar
12Boulton, AJ, Malik, RA. Diabetic neuropathy. Med Clin North Am 1998;82:909–29Google Scholar
13Davies, M, Brophy, S, Williams, R, Taylor, A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006;29:1518–22Google Scholar
14Halum, SL, Sycamore, DL, McRae, BR. A new treatment option for laryngeal sensory neuropathy. Laryngoscope 2009;119:1844–7Google Scholar
15Belafsky, PC, Postma, GN, Koufman, JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16:274–7Google Scholar
16Bauchau, V, Philippart, D, Durham, S. A simple and efficient screening tool for allergic rhinitis. Poster presented at: 23rd Congress of the European Academy of Allergology and Clinical Immunology; June 12–16, 2004; Amsterdam, The Netherlands.Google Scholar
17Amin, MR, Koufman, JA. Vagal neuropathy after upper respiratory infection: a viral etiology? Am J Otolaryngol 2001;22:251–6Google Scholar
18Bastian, RW, Vaidya, AM, Delsupehe, KG. Sensory neuropathic cough: a common and treatable cause of chronic cough. Otolaryngol Head Neck Surg 2006;135:17–21Google Scholar
19Lee, B, Woo, P. Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. Ann Otol Rhinol Laryngol 2005;114:253–7Google Scholar
20Aviv, JE, Kim, T, Thomson, JE, Sunshine, S, Kaplan, S, Close, LG. Fiberoptic endoscopic evaluation of swallowing with sensory testing (FEESST) in healthy controls. Dysphagia 1998;13:87–92Google Scholar
21Bock, JM, Blumin, JH, Toohill, RJ, Merati, AL, Prieto, TE, Jaradeh, SS. A new noninvasive method for determination of laryngeal sensory function. Laryngoscope 2011;121:158–63Google Scholar
22Burde, RM, Savino, PJ, Trobe, JD. Clinical Decisions in Neuro-Ophthalmology. St Louis, MO: Mosby, 1984Google Scholar
23Feldman, M, Schiller, LR. Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 1983;98:378–84Google Scholar
24Wang, X, Pitchumoni, CS, Chandrarana, K, Shah, N. Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol 2008;14:709–12Google Scholar
25Bytzer, P, Talley, NJ, Leemon, M, Young, LJ, Jones, MP, Horowitz, M. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 2001;161:1989–96Google Scholar
26The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977–86Google Scholar
27Gastre, B, Hirsh, IB. The effects of improved glycemic control on complications in type 2 diabetes. Arch Intern Med 1998;158:134–40Google Scholar
28Mohseni, S. Hypoglycemic neuropathy in diabetic BB/Wor rats treated with insulin implants affects ventral root axons but not dorsal root axons. Acta Neuropathol 2000;100:415–20Google Scholar
29MacLean, DB. Substance P and somatostatin content and transport in vagus and sciatic nerves of the streptozocin-induced diabetic rat. Diabetes 1987;36:390–5Google Scholar
30Norris, BK, Schweinfurth, JM. Management of recurrent laryngeal sensory neuropathic symptoms. Ann Otol Rhinol Laryngol 2010;119:188–91Google Scholar