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Ketamine in the management of generalised cephalic tetanus

Published online by Cambridge University Press:  26 November 2007

O Obanor ,
H O Osazuwa  and
J E O Amadasun
O Obanor
Affiliation:
Dr Amadasun Ear Care Institute, Westend Hospital, Warri, Nigeria
H O Osazuwa
Affiliation:
Dr Amadasun Ear Care Institute, Westend Hospital, Warri, Nigeria
J E O Amadasun*
Affiliation:
Dr Amadasun Ear Care Institute, Westend Hospital, Warri, Nigeria
*
Address for correspondence: Dr John E O Amadasun, Dr Amadasun Ear Care Institute, Westend Hospital, 1, 25th Street, Airport Road, Effurun PO Box 753, Warri, Nigeria. E-mail: [email protected]
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Abstract

Background:

Tetanus is a fatal infection caused by the neurotoxin tetanospasmin released by the vegetative spores of Clostridium tetani. The high mortality rate is related to frequent tetanic fits with laryngeal spasm and airway obstruction. Numerous anticonvulsants are in use, with varying efficacy in controlling fits. This case report highlights the use of ketamine as adjunctive therapy in the management of tetanus.

Case report:

A 20-year-old woman was admitted with a history of recurrent left ear pain, with bloody, purulent discharge, following a self-inflicted injury. She developed tetanic spasms 24 hours after admission. She had received no immunisations. A tracheostomy was established to relieve airway obstruction, and ketamine was added to the medication when breakthrough seizures were refractory to diazepam.

Conclusion:

Ketamine is of proven safety as an anaesthetic agent, especially in cases in which an anaesthetist is not readily available. Its effectiveness in this case, in combination with diazepam, warrants further evaluation.

Keywords

Clostridium TetaniTetanusAirway ObstructionKetamine
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 12 , December 2008 , pp. 1389 - 1391
Copyright
Copyright © JLO (1984) Limited 2007

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