Hostname: page-component-669899f699-chc8l Total loading time: 0 Render date: 2025-04-25T17:10:13.707Z Has data issue: false hasContentIssue false
  • English
  • Français

Keratin antibody localization in head and neck tissues and neoplasms

Published online by Cambridge University Press:  29 June 2007

Shan-Rong Shi ,
Atul K. Bhan ,
Ben Z. Pilch ,
Lan Bo Chen  and
Max L. Goodman
Shan-Rong Shi
Affiliation:
Department of Otolaryngology Pathology, Massachusetts Eye and Ear Infirmary.
Atul K. Bhan
Affiliation:
James Homer Wright Pathological Laboratories, Massachusetts General Hospital.
Ben Z. Pilch
Affiliation:
Department of Otolaryngology Pathology, Massachusetts Eye and Ear Infirmary. James Homer Wright Pathological Laboratories, Massachusetts General Hospital.
Lan Bo Chen
Affiliation:
Dana-Farber Cancer Institue, Harvard Medical School.
Max L. Goodman*
Affiliation:
Department of Otolaryngology Pathology, Massachusetts Eye and Ear Infirmary. James Homer Wright Pathological Laboratories, Massachusetts General Hospital.
*
Max L. Goodman, M.D. Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Mass. 02114, U.S.A.
Get access Rights & Permissions [Opens in a new window]

Abstract

Immunohistochemical staining for keratin proteins may be useful as a diagnostic parameter in head and neck neoplasms. Our study evaluates the keratin antibody staining properties of normal tissues as well as neoplastic and non-neoplastic head and neck lesions from surgical procedures performed on 100 patients. The results indicate that the anti-keratin antibody technique can be helpful in several areas of head and neck pathology.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 98 , Issue 12 , December 1984 , pp. 1241 - 1250
Copyright
Copyright © JLO (1984) Limited 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Asch, B. B., Burstein, N. A., Vidrich, A., and Sun, T.-T. (1981) Identification of mouse mammary epithelial cells by immunofluorescence with rabbit and guinea pig antikeratin antisera. Proceedings of the National Academy of Sciences of the United States of America, 78: 5643–5647.CrossRefGoogle ScholarPubMed
Battifora, H., Sun, T. T., Baht, R., and Rao, S. (1980) The use of antikeratin antiserum in tumour diagnosis. Laboratory Investigation, 42: 100–101.Google Scholar
Carbone, A. and Micheau, C. (1982) Pitfalls in microscopic diagnosis of undifferentiated carcinoma of nasopharyngeal type (lymphoepithelioma). Cancer, 50: 1344–1351.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Feanke, W. W., Weber, K., Osborn, M., Schmid, E., and Freudenstein, C. (1978) Antibody to pre-keratin, Decoration of tonofilament-like arrays in various cells of epithelial character. Experimental Cell Research, 116: 429–445.Google Scholar
Gray, R. H., Brabec, R. K., Byrsk, M. M., and Bernstein, I. A. (1977) Immunocytochemical localization of a protein in tonofilaments as a morphologic marker for epidermal differentiation. Journal of Histochemistry and Cytochemistry, 25: 1127–1139.CrossRefGoogle ScholarPubMed
Madri, J. A. and Barwick, K. W. (1982) An immunohistochemical study of nasopharyngeal neoplasms using kertatin antibodies. American Journal of Surgical Pathology, 6: 143–149.CrossRefGoogle ScholarPubMed
Schlegel, R., Banks-Schlegel, S., McLeod, J. A., and Pinkus, G. S. (1980a) Immunoperoxidase localization of keratin in human neoplasms, A preliminary survey. American Journal of Pathology, 101: 41–50.Google ScholarPubMed
Schlegel, R., Banks-Schlegel, S., and Pinkus, G. S. (1980b) Immunohistochemical localization of keratin in normal human tissues. Laboratory Investigation, 42: 91–96.Google ScholarPubMed
Sun, T.-T. and Green, H. (1978a) Immunofluorescent staining of keratin fibers in cultured cells. Cell, 14: 469–476.CrossRefGoogle ScholarPubMed
Sun, T.-T. and Green, H. (1978b) Keratin filaments of cultured human epidermal cells, formation of intermolecular disulfide bonds during terminal differentiation. Journal of Biological Chemistry, 253: 2053–2060.CrossRefGoogle ScholarPubMed
Sun, T.-T., Shih, C, and Green, H. (1979) Keratin cytoskeletons in epithelial cells of internal organs. Proceedings of the National Academy of Sciences of the United States of A merica, 76: 2813–2817.CrossRefGoogle ScholarPubMed
Summerhayes, I. C. and Chen, L. B. (1982) Localization of a Mry 52,000 keratin in basal epithelial cells of the mouse bladder and expression throughout neoplastic progression. Cancer Research, 42: 4098–4109.Google Scholar
Woods, G. L., Espinoza, C. G., and Azar, H. A. (1982) Carcinomas with spindle cell (sarcomatoid) component: An immunocytochemical and electron microscopic study. Laboratory Investigation, 46: 91A.Google Scholar