Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-28T17:36:30.187Z Has data issue: false hasContentIssue false
  • English
  • Français

Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps?

Published online by Cambridge University Press:  05 July 2018

O Ismi ,
T Kara ,
G Polat ,
O Bobusoglu ,
Y Vayısoglu ,
K Gorur  and
C Ozcan
O Ismi*
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
T Kara
Affiliation:
Department of Pathology, University of Mersin, Turkey
G Polat
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Mersin, Turkey
O Bobusoglu
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Mersin, Turkey
Y Vayısoglu
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
K Gorur
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
C Ozcan
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
*
Author for correspondence: Dr Onur Ismi, Mersin Üniversitesi Tıp Fakültesi Hastanesi, Kulak Burun Boğaz AD, Çiftlikköy Kampüsü, Çiftlikköy/Yenişehir, Mersin, Turkey Fax: +90 3242 380 091 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.

Methods

The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.

Results

Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund–Mackay scores (p = 0.792).

Conclusion

Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.

Keywords

Nasal PolypsNeurotrophin 3Inflammation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 8 , August 2018 , pp. 724 - 728
Copyright
Copyright © JLO (1984) Limited, 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr O Ismi takes responsibility for the integrity of the content of the paper

References

1Pawankar, R. Nasal polyposis: an update. Curr Opin Allergy Clin Immunol 2003;3:1–6Google Scholar
2Pawankar, R, Nonaka, M. Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep 2007;7:202–8Google Scholar
3Coffey, CS, Mulligan, RM, Schlosser, RJ. Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. Am J Rhinol Allergy 2009;23:571–4Google Scholar
4Terzakis, D, Georgalas, C. Polyps, asthma and allergy: what's new. Curr Opin Otolaryngol Head Neck Surg 2017;25:12–18Google Scholar
5Li, QC, Cheng, KJ, Wang, F, Zhou, SH. Role of atopy in chronic rhinosinusitis with nasal polyps: does an atopic condition affect the severity and recurrence of disease? J Laryngol Otol 2016;130:640–4Google Scholar
6Aversa, S, Ondolo, C, Abbadessa, G, Piccione, F, Carriero, V, Fulcheri, A et al. Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-1β. Rhinology 2012;50:427–35Google Scholar
7Ozcan, C, Tamer, L, Ates, NA, Gorur, K. The glutathione-s-transferase gene polymorphisms (Gstt1, Gstm1, and Gstp1) in patients with non-allergic nasal polyposis. Eur Arch Otorhinolaryngol 2010;267:227–32Google Scholar
8Nockher, WA, Renz, H. Neurotrophins and asthma: novel insight into neuroimmune interaction. J Allergy Clin Immunol 2006;117:67–71Google Scholar
9Jornot, L, Grouzmann, E, Lacroix, JS, Rochat, T. BDNF and DPP-IV in polyps and middle turbinates epithelial cells. Rhinology 2007;45:129–33Google Scholar
10Ismi, O, Ozcan, C, Karabacak, T, Polat, G, Vayisoglu, Y, Gucluturk, T et al. Local effect of neurotrophin-3 in neuronal inflammation of allergic rhinitis: preliminary report. Balkan Med J 2015;32:364–70Google Scholar
11Raap, U, Fokkens, W, Bruder, M, Hoogsteden, H, Kapp, A, Braunstahl, GJ. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy 2008;63:468–75Google Scholar
12Gelincik, A, Aydin, F, Ozerman, B, Erguven, M, Aydın, S, Bilir, A et al. Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis. Ann Allergy Asthma Immunol 2012;108:396–401Google Scholar
13Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:1–12Google Scholar
14Bateman, ED, Hurd, SS, Barnes, PJ, Bousquet, J, Drazen, JM, FitzGerald, M et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143–78Google Scholar
15Lund, VJ, Mackay, IS. Staging in rhinosinusitis. Rhinology 1993;31:183–4Google Scholar
16Barcena de Arellano, ML, Wagner, MF, Oldeweme, J, Arnold, J, Ebert, A, Schneider, A et al. Neurotrophin expression is not affected in uteri of women with adenomyosis. J Mol Neurosci 2012;47:495–504Google Scholar
17Ozcan, C, Zeren, H, Talas, DU, Kucukoglu, M, Gorur, K. Antrochoanal polyp: a transmission electron and light microscopic study. Eur Arch Otorhinolaryngol 2005;262:55–60Google Scholar
18Dennis, SK, Lam, K, Luong, A. A review of classification schemes for chronic rhinosinusitis with nasal polyposis endotypes. Laryngoscope Investig Otolaryngol 2016;1:130–4Google Scholar
19Raap, U, Braunstahl, GJ. The role of neurotrophins in the pathophysiology of allergic rhinitis. Curr Opin Allergy Clin Immunol 2010;10:8–13Google Scholar
20Manti, S, Brown, P, Perez, MK, Piedimonte, G. The role of neurotrophins in inflammation and allergy. Vitam Horm 2017;104:313–41Google Scholar
21Noga, O, Englmann, C, Hanf, G, Grützkau, A, Seybold, J, Kunkel, G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy 2003;33:649–54Google Scholar
22Kobayashi, H, Gleich, GJ, Butterfield, JH, Kita, H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood 2002;99:2214–20Google Scholar
23Wu, X, Myers, AC, Goldstone, AC, Togias, A, Sanico, AM. Localization of nerve growth factor and its receptors in the human nasal mucosa. J Allergy Clin Immunol 2006;118:428–33Google Scholar
24Beatrice, F, Aluffi, P, Bottomicca, F, Perlasco, L, Sartoris, A. Nasal polyps and substance P: a preliminary report [in Italian]. Acta Otorhinolaryngol Ital 1994;14(suppl 41):35–9Google Scholar
25Gungor, A, Baroody, FM, Naclerio, RM, White, SR, Corey, JP. Decreased neuropeptide release may play a role in the pathogenesis of nasal polyps. Otolaryngol Head Neck Surg 1999;121:585–90Google Scholar