Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-28T04:58:48.044Z Has data issue: false hasContentIssue false
  • English
  • Français

Is there a role for flexible oesophagogastroscopy in upper aerodigestive tract squamous cell carcinoma?

Published online by Cambridge University Press:  25 November 2009

T J Beech ,
M I Trotter ,
A L McDermott ,
W Mandal  and
A J Batch
T J Beech*
Affiliation:
ENT department, City Hospital, Birmingham, UK
M I Trotter
Affiliation:
ENT department, City Hospital, Birmingham, UK
A L McDermott
Affiliation:
ENT department, City Hospital, Birmingham, UK
W Mandal
Affiliation:
ENT department, City Hospital, Birmingham, UK
A J Batch
Affiliation:
ENT department, City Hospital, Birmingham, UK
*
Address for correspondence: Mr T J Beech, City Hospital, Dudley Road, Birmingham B18 7QH, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Introduction:

There is growing evidence to suggest that reflux (both laryngopharyngeal and gastroesophageal) has a role in the development of upper aerodigestive tract squamous cell carcinoma. This study discusses the role of identifying reflux in this patient group, and its prevalence.

Methods:

Prospective review of patients with head and neck cancer undergoing flexible oesophagogastroscopy as part of their diagnostic investigation.

Results:

Forty-five consecutive patients were identified. All patients were found to have evidence of oesophagitis, with 28 having oesophageal erosions and two Barrett's oesophagitis.

Conclusion:

Flexible oesophagogastroscopy is a useful test in patients with upper aerodigestive tract squamous cell carcinoma.

Keywords

Gastro-esophageal RefluxHead And Neck NeoplasmsEndoscopesGastrointestinal
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 4 , April 2010 , pp. 417 - 419
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented as a poster at the Third World Congress of the International Federation of Head and Neck Oncological Societies, May 2008, Venue Zagreb, Croatia.

References

1 Bacciu, A, Mercante, G, Ingegnoli, A, Ferri, T, Muzzetto, P, Leandro, G et al. Effects of gastroesophageal reflux disease in laryngeal carcinoma. Clin Otolaryngol 2004;29:545–8CrossRefGoogle ScholarPubMed
2 Mercante, G, Bacciu, A, Ferri, T, Bacciu, S. Gastroesophageal reflux as a possible co-promoting factor in the development of the squamous-cell carcinoma of the oral cavity, of the larynx and of the pharynx. Acta Otorhinolaryngologica Belgica 2003;57:113–17Google ScholarPubMed
3 Assimakopoulos, D, Patrikakos, G. The role of gastroesophageal reflux in the pathogenesis of laryngeal carcinoma. Am J Otolaryngol 2002;23:351–7CrossRefGoogle ScholarPubMed
4 Galli, J, Cammarota, G, Calo, L, Agostino, S, D'Ugo, D, Cianci, R et al. The role of acid and alkaline reflux in laryngeal squamous cell carcinoma. Laryngoscope 2002;112:1861–5CrossRefGoogle ScholarPubMed
5 Freije, JE, Beatty, TW, Campbell, BH, Woodson, BT, Schultz, CJ, Toohill, RJ. Carcinoma of the larynx in patients with gastroeosophageal reflux. Am J Otolaryngol 1996;17:386–90CrossRefGoogle Scholar
6 Qadeer, MA, Lopez, R, Wood, BG, Esclamado, R, Strome, M, Vaezi, MF. Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence? Laryngoscope 2005;115:1877–81CrossRefGoogle ScholarPubMed
7 Biacabe, B, Gleich, LL, Laccourreye, O, Hartl, DM, Bouchoucha, M, Brasnu, D. Silent gastroesophageal reflux disease in patients with pharyngolaryngeal cancer: further results. Head Neck 1998;20:510–143.0.CO;2-0>CrossRefGoogle ScholarPubMed
8 Savary, M, Miller, G. The Esophagus: Handbook and Atlas of Endoscopy. Solothurn, Switzerland: Verlag Gassman, 1978;135–42Google Scholar
9 Bochud, M, Gonvers, JJ, Vader, JP, Dubois, RW, Burnand, B, Froehlich, F. Appropriateness of gastroscopy: gastro-esophageal reflux disease. Endoscopy 1999;31:596–603CrossRefGoogle ScholarPubMed
10 Amano, Y, Ishimura, N, Furuta, K, Okita, K, Masaharu, M, Azumi, T et al. Interobserver agreement on classifying endoscopic diagnoses of nonerosive esophagitis. Endoscopy 2006;38:1032–5CrossRefGoogle ScholarPubMed
11 Steer, CB, Harper, PG. Gastro-oesophageal complications in patients receiving cancer therapy: the role of proton pump inhibitors. Eur J Gastroenterol Hepatol 2002;14:S17–21Google ScholarPubMed
12 DeVault, KR, Castell, DO. Guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Practice Parameters Committee of the American College of Gastroenterology. Arch Int Med 1995;155:2165– 73CrossRefGoogle ScholarPubMed
13 Koufmann, JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101(suppl 53):1–78CrossRefGoogle Scholar
14 Koufmann, JA, Wiener, GJ, Wu, WC, Castell, DO. Reflux laryngitis and its sequelae: the diagnostic role of ambulatory 24-hour pH monitoring. J Voice 1988;2:78–89CrossRefGoogle Scholar