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Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature

Published online by Cambridge University Press:  05 February 2016

M A Bitar ,
J Nassar  and
R Dana
M A Bitar*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Medical Center, American University of Beirut, Lebanon Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and Medical Center, American University of Beirut, Lebanon Department of ENT Surgery, Children's Hospital at Westmead, Sydney, Australia Pediatric Otolaryngology Program, Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates
J Nassar
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Medical Center, American University of Beirut, Lebanon Department of Otolaryngology Head and Neck Surgery, King Abdulaziz Medical City – National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia
R Dana
Affiliation:
private clinic (paediatrics), Beirut, Lebanon
*
Address for correspondence: Dr Mohamad A Bitar, Pediatric Otolaryngology Program, Al Jalila Children's Specialty Hospital, PO Box 7662, Dubai, UAE E-mail: [email protected]
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Abstract

Objectives:

To study and review the short- and long-term effects of intranasal steroids on obstructive adenoids.

Methods:

In this prospective cohort study, 19 children previously treated with mometasone furoate for 3 months were contacted at 3, 6 and 12 months after cessation of treatment. Main outcome measures included: change in severity of nasal obstruction, allergic rhinitis and obstructive symptoms. A systematic review of literature was also performed.

Results:

By one year, 25 per cent of patients required adenoidectomy; the remaining children had no significant change in clinical score (p = 0.464), obstruction severity (p = 0.191) or allergic symptoms (p = 0.284). Fourteen pertinent studies were identified; all but one study showed improvement in the patients’ symptoms and/or degree of obstruction. Two studies with follow up reaching 25 months showed positive effects.

Conclusion:

The short-term positive effect of some intranasal steroids on obstructive adenoids seems to persist in a significant number of patients after the cessation of treatment.

Keywords

AdenoidNasal ObstructionIntranasal Drug AdministrationSteroidsFollow-Up StudiesMometasone Furoate
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 4 , April 2016 , pp. 357 - 362
Copyright
Copyright © JLO (1984) Limited 2016 

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Footnotes

Presented at the Australian Society of Otolaryngology Head and Neck Surgery Annual Scientific Meeting, 29 March – 1 April 2014, Brisbane, Australia.

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