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Is injectable collagen truly safe?

Published online by Cambridge University Press:  29 June 2007

Etsuyo Takayama ,
Makoto Ikeda ,
Sumiaki Tsuru ,
Masami Ogura ,
Satoshi Kitahara ,
Tetsuzo Inouye  and
Gerald B. Healy
Etsuyo Takayama*
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Makoto Ikeda*
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Sumiaki Tsuru
Affiliation:
Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Masami Ogura
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Satoshi Kitahara
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Tetsuzo Inouye
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Gerald B. Healy
Affiliation:
Department of Otology and Laryngology, Havard Medical School, Boston, USA.
*
Dr Etsuyo Takayama and Dr Makoto Ikeda, Department of Otolaryngology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359, Japan
Dr Etsuyo Takayama and Dr Makoto Ikeda, Department of Otolaryngology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359, Japan
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Abstract

Most patients have no response to injectable collagen or silicone, but some cases may have positive or ‘undersea’(= clinically negative but immunologically positive) response to collagen. From the results of the Macrophage migration inhibition test, the relative immunogenicity was augmented most when we used implants with the following combination. The firstimmunization was collagen and the second one was collagen with silicone.

The augmented antigenicity might be enough to cause an allergic reaction to the patients who had no response to each implant alone. The purpose of this article is to warn of the potential hazard of injection.

Keywords

InjectioncollagenSilicone
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 8 , August 1992 , pp. 704 - 708
Copyright
Copyright © JLO (1984) Limited 1992

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