Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-05T03:24:00.323Z Has data issue: false hasContentIssue false
  • English
  • Français

Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction?

Published online by Cambridge University Press:  29 June 2007

Josephine Marriage  and
N. M. Barnes
Josephine Marriage*
Affiliation:
Department of Audiology, Addenbrooke's NHS Trust, Cambridge
N. M. Barnes
Affiliation:
Department of Pharmacology, The Medical School, Edgbaston, Birmingham, UK.
*
Ms J. Marriage, Audiology Dept, Addenbrookes Hospital, Cambridge CB2 2QQ.
Get access Rights & Permissions [Opens in a new window]

Abstract

The subjective symptom of hyperacusis is described. The terms ‘hyperacusis’ and ‘phonophobia’ are considered to be synonymous as there is no recognized distinction between these two descriptions. Peripheral auditory pathologies with associated hearing sensitivity are reviewed and the likely mechanisms underlying the hyperacusis are listed. The neurological conditions, which have been reported to occur with hyperacusis, are reviewed. A separate aetiology of central hyperacusis is therefore proposed, with a symptom profile distinct from the peripheral hyperacusis

A common factor to neurological conditions with hyperacusis, is disturbance of 5-HT (5-hydroxytryptamine) or serotonin function. The research literature on the role of 5-HT in sensory modulation (specifically auditory startle) in animals is presented. It is proposed that 5-HT dysfunction is a probable cause of increased auditory sensitivity manifested as central hyperacusis or phonophobia

Keywords

SerotoninHyperacusis
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 10 , October 1995 , pp. 915 - 921
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adour, K. K. (1982) Diagnosis and management of facial, paralysis. New England Journal of Medicine 307: 307–348.CrossRefGoogle ScholarPubMed
Andorn, A. C., Vittorio, J. A., Bellflower, J. (1989) 3H-spiroperidol binding occurs at multiple high affinity states with serotonergic selectivity. Psychopharmacology 99: 99–520.CrossRefGoogle ScholarPubMed
ARRI (1990) Autism Research Review International Editorial Vol 4(4): San Diego ARI, 1990.Google Scholar
Axelsson, A., Anari, M. (1993) Hyperacusis. From Symposium and Summer Course in Psychoacoustics Oldenburg, Germany, September 1993.Google Scholar
Bakheit, A. M. O., Behan, P. O., Dinan, T. G., Gray, C. E., O'Keane, V. (1992) Possible up regulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome. British Medical Journal 304: 304–1010.CrossRefGoogle Scholar
Beeley, L. (1991) Benzodiazepines and tinnitus. British Medical Journal 302: p 1465.CrossRefGoogle ScholarPubMed
Behan, P. O., Bakheit, A. M. O. (1991) Clinical spectrum of postviral fatigue syndrome. British Medical Bulletin 47: 47–739.CrossRefGoogle ScholarPubMed
Berman, J. L., Justice, P., Hsia, D. Y. Y. (1969) Effect of vitamin B6 on blood 5-HT concentration. Annals of New York Academy of Science 166: 97.Google ScholarPubMed
Blier, P., DeMontigny, C. (1994) Current advances and trends in the treatment of depression. Trends in Pharmacological Sciences 15: 15–220.CrossRefGoogle ScholarPubMed
Brewerton, T. D., Murphy, D. L., Mueller, E. A., Jimerson, D. C. (1988) Induction of migraine-like headaches by the serotonin agonist m-chlorophenylpiperazine. Clinical Pharmacology and Therapeutics 43: 43–605.CrossRefGoogle Scholar
Butler, S. (1993) Personal communication from Burden Neurological Institute, Bristol.Google Scholar
Carmen, J. S. (1973) Imipramine in hyperacusic depression. American Journal of Psychiatry 130: 937.CrossRefGoogle Scholar
Cawthorne, T. (1948) Ménière's disease. Proceedings of the Royal Society of Medicine 41: 41–803.Google Scholar
Cassella, J. V., Davis, M. (1986) Habituation, prepulse inhibition, fear-conditioning and drug modulation of the acoustically elicited pinna reflex in rats. Behavioural Neuroscience 100: 100–39.CrossRefGoogle ScholarPubMed
Coleman, M. (1973) Serotonin in Down's syndrome, Ch. 7, (Coleman, M., ed.) American Elsevier Publishing Co., New York pp 117–134.Google Scholar
Coles, R. R. A., Sood, S. K. (1988) Hyperacusis and phonophobia in tinnitus patients. British Journal of Audiology 22: 22–228.Google Scholar
Collet, L., Roge, B., Descouens, D., Moron, P., Duverdy, F., Urgell, H. (1993) Objective auditory dysfunction in infantile autism. Lancet 342: 923–924 (Letter to Editor).CrossRefGoogle ScholarPubMed
Craig, D. A., Clarke, D. E. (1991) Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation. British Journal of Pharmacology 102: 102–563.CrossRefGoogle ScholarPubMed
Davis, M., Astrachan, D. I., Kass, E. (1980) Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle. Science 209: 209–521.CrossRefGoogle ScholarPubMed
Davis, M., Cassella, J. V., Wrean, W. H., Kehne, J. H. (1986) Serotonin receptor subtype agonists: differential effects on sensorimotor reactivity measured with acoustic startle. Psychopharmacology Bulletin 22: 22–837.Google ScholarPubMed
Davis, M. (1989) The role of the amygdala and its efferent projections in fear and anxiety. In Psychopharmacology of Anxiety. (Tyrer, P., ed.), Oxford University Press, Oxford, pp 52–79.Google Scholar
Dorland's Illustrated Medical Dictionary (1988) 27th Edition. W. B. Saunders Co., Philadelphia.Google Scholar
Eybalin, M. (1993) Neurotransmitters and neuromodulators of the mammalian cochlea. Physiological Reviews 73: 73–309.CrossRefGoogle ScholarPubMed
Fozard, J. R., Kalkman, K. O. (1992) 5-HT in nervous system disease and migraine. Current Opinion in Neurology and Neurosurgery 5: 5–496.Google ScholarPubMed
Fozard, J. R., Kalkman, K. O. (1994) 5-HT and the initiation of migraine: new perspectives. Naunyn-Schmied Archives of Pharmacology 350: 350–225.CrossRefGoogle ScholarPubMed
Fozard, J. R., Mir, A. K., Ramage, A. G. (1989) 5-HT Receptors and cardiovascular control. In Serotonin, Actions, Receptors, Pathophysiology. (Mylecharane, E. J., Angus, J. A., de la Lande, I. S., Humphrey, P. P. A., eds.), Macmillan Press, London, pp 146–151.CrossRefGoogle Scholar
Fujinawa, A., Kawai, I., Ohashi, H., Kimura, S. (1977) A case of musicogenic epilepsy. Folia Psychiatry and Neurology (Japan) 31: 31–463.Google ScholarPubMed
Fukaya, T., Nomura, Y. (1988) Audiological aspects of idiopathic perilymph fistula. Acta Otolaryngologica Stockholm 456 (suppl.): 68–73.CrossRefGoogle Scholar
Gascon, G. G., Ozand, P. T., Erwin, R. E. (1992) G-sub (Ml) gangliosidosis type 2 in two siblings. Journal of Child Neurology 7 (suppl.) 41–50.CrossRefGoogle Scholar
Gordon, A. G. (1983) Meniere's disease: endolymphatic hypertension or perilymphatic hypotension? Clinical Otolaryngology 8: 8–293.CrossRefGoogle Scholar
Gordon, B. A., Gordon, K. E., Hinton, G. G., Cadera, W., Feleki, V., Bayleran, J., Hechtman, P. (1988) Tay-Sachs disease: Bl variant. Pediatric Neurology 4: 4–54.CrossRefGoogle Scholar
Harrop-Griffiths, J., Katon, W., Dobie, R., Sakai, C., Russo, J. (1987) Chronic tinnitus: association with psychiatric diagnoses. Journal of Psychosomatic Research 31: 31–613.CrossRefGoogle ScholarPubMed
Hazell, J. W. P., Sheldrake, J. B. (1991) Hyperacusis and tinnitus. In Proceedings IV International Tinnitus Seminar, Bordeaux. (Aran, J-M., Dauman, R., eds.), Kugler, Ghedini Publications Amsterdam, 245–248.Google Scholar
Heller, M. F., Bergman, M. (1953) Tinnitus in normallyhearing persons. Annals of Otology, Rhinology and Laryngology 62: 62–73.CrossRefGoogle Scholar
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., Humphrey, P. P. (1994) International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacological Reviews 46: 46–157.Google ScholarPubMed
Ison, J. R., MacAdam, D. W., Hammond, G. R. (1973) Latency and amplitude changes in the acoustic startle reflex of the rat produced by variation in auditory pre-stimulation. Physiology and Behaviour 10: 10–1035.CrossRefGoogle Scholar
Iversen, S. D. (1984) 5-HT and anxiety. Neuropharmacology 23: 23–1553.CrossRefGoogle ScholarPubMed
Jakeman, P. M., Hawthorne, J. E., Maxwell, S. R. J., Kendall, M. J., Holder, G. (1994) Evidence for down regulation of hypothalamic 5-HT receptor function in endurance-trained athletes. Experimental Physiology 79: 79–461.CrossRefGoogle ScholarPubMed
Jastreboff, P. J., Hazell, J. W. P. (1993) A neurophysiological approach to tinnitus: clinical implications. British Journal of Audiology 27: 27–7.CrossRefGoogle ScholarPubMed
Kalkman, H. O., Fozard, J. R. (1991) 5HT receptor types and their role in disease. Current Opinion in Neurology and Neurosurgery 4: 4–560.Google Scholar
Kennett, G. A., Whitton, P., Shah, K., Curzon, G. (1989) Anxiogenic-like effects on mCPP and TFMPP in animal models are opposed by 5HT1C receptor antagonists. European Journal of Pharmacology 164: 164–445.CrossRefGoogle ScholarPubMed
Lader, M. (1984) Benzodiazepine dependence. Progress in Neuropsychopharmacology and Biological Psychiatry 8: 85–95.CrossRefGoogle ScholarPubMed
Lance, J. W. (1991) 5-HT and its role in migraine. European Neurology 31: 31–279.CrossRefGoogle ScholarPubMed
Langer, S. Z. (1989) Behavioural actions of 5-hydroxytryptamine: an overview. In Serotonin, Actions, Receptors, Pathophysiology. Ch. 14. (Mylecharane, E. J., Angus, J. A., de La Lande, I. S., Humphrey, P. P. A., eds.), Macmillan Press, London, pp 109–112.CrossRefGoogle Scholar
Laurian, N., Laurian, L., Sandov, R. (1983) New clinical applications of the stapedial reflex. Journal of Laryngology and Otology 97: 97–1099.CrossRefGoogle ScholarPubMed
Mangham, C. A. (1984) The effect of drugs and systemic disease on the acoustic reflex. In The Acoustic Reflex: Basic Principles and Clinical Applications. (Silman, S., ed.) Acadmic Press, Orlando, p 441–468.CrossRefGoogle Scholar
Marcus, D. A., Soso, M. J. (1989) Migraine and stripe induceddiscomfort. Archives of Neurology 46: 46–1129.CrossRefGoogle Scholar
Marsden, C. A. (1989) 5-hydroxytryptamine receptor subtypes and new anxiolytic drugs: an appraisal. In Psychopharmacology of Anxiety. (Tyrer, P., ed.), Oxford University Press, Oxford, pp 3–27.Google Scholar
Mathisen, H. (1969) Phonophobia after stapedectomy. Ada Otolaryngologica 68: 68–73.Google ScholarPubMed
McCandless, G. A., Goering, D. M. (1974) Changes in loudness after stapedectomy. Archives of Otolaryngology 100: 100–344.Google ScholarPubMed
Meltzer, H. Y. (1990) Role of serotonin in depression. Annals of New York Academy of Science 600: 600–486.CrossRefGoogle ScholarPubMed
Merry, P. (1991) Post-Viral Fatigue Syndrome, (Jenkins, R., Mowbray, J., eds.), John Wiley, Chichester, p 289.Google Scholar
Moore, B. C. J., Glasberg, B. R., Hess, R. F., Birchall, J. P. (1985) Effects of flanking noise bands on the rate of growth loudness of tones in normal and recruiting ears. Journal of Acoustic Society of America 77(4): 1505–1513.CrossRefGoogle ScholarPubMed
Muskowitz, M. A., Cutner, F. M. (1993) Sumatripan - a receptor-targeted treatment for migraine. Annual Review of Medicine 44: 44–145.Google Scholar
Oppe, T. (1992) Professor of Paediatrics, St Mary's Medical School, London. (Personal communication).Google Scholar
Owens, M. J., Nemeroff, C. D. (1994) Role of serotonin in the pathophysiology of depression - focus on the serotonin transporter. Clinical Chemistry 40: 40–288.CrossRefGoogle ScholarPubMed
Phillips, H. C., Hunter, M. (1982) A laboratory technique for the assessment of pain behaviour. Journal of Behavioural Medicine 5(3): 283–294.CrossRefGoogle Scholar
Priede, V. M., Coles, R. R. A. (1971) Factors influencing the loudness discomfort level. Sound 5: 5–339.Google Scholar
Reich, G. E., Griest, S. E. (1992) A survey of hyperacusis patients. In Tinnitus 91: Proceedings of the Fourth International Tinnitus Seminar. (Aran, J-M., Dauman, R., eds.), Kugler Publications, Amsterdam, pp 249–253.Google Scholar
Rocco, P. L., Giavedoni, A., Pacella, G. (1992) Withdrawal from benzodiazepines in a hospital setting - an open trial with buspirone. Current Therapeutic Research 52: 52–386.CrossRefGoogle Scholar
Schain, R. J., Freedman, D. X. (1961) Studies on 5-Hydroxyindol metabolism in autistic and other mentally retarded children. Journal of Pediatrics 58: 58–315.CrossRefGoogle Scholar
Sharma, S. K., Dakshinamurti, K. (1994) Effects of serotonergic agents on plasma prolactin levels in pyridoxinedeficient adult male rats. Neurochemical Research 19: 19–687.CrossRefGoogle ScholarPubMed
Solomon, S., Lipton, R. B., Newman, L. C. (1992) Clinical features of daily headache. Headache 32: 32–325.CrossRefGoogle ScholarPubMed
Stephens, S. D. G. (1970) Studies on the uncomfortable loudness level. Sound 4: 4–20.Google Scholar
Subcutaneous Sumatriptan International Study Group (SSISG) (1991) Treatment of migraine attacks with sumatriptan. New England Journal of Medicine 325(5): 316–321.CrossRefGoogle Scholar
Thompson, G. C., Thompson, A. M., Garrett, K. M., Britton, B. H. (1994) Serotonin and serotonin receptors in the central auditory system. Otolaryngology - Head and Neck Surgery 110: 110–93.CrossRefGoogle ScholarPubMed
Thornton, A. R. D., Farrell, G., McSporran, E. L (1989) Clinical methods for the objective estimation of loudness discomfort level (LDL) using auditory brain stem responses in patients. Scandinavian Audiology 18: 18–225.CrossRefGoogle ScholarPubMed
Tyler, R. S., Baker, L. J. (1983) Difficulties experienced by tinnitus sufferers. Journal of Speech and Hearing Disorders 48: 48–150.CrossRefGoogle ScholarPubMed
Vernon, J. A. (1987) Pathophysiology of tinnitus: a special case - hyperacusis and a proposed treatment. American Journal of Otology 8: 8–201.Google Scholar
Wayman, D. M., Pham, H. N., Byl, F. M., Adour, K. K. (1990) Audiological manifestations of Ramsay Hunt syndrome. Journal of Laryngology and Otology 104: 104–104.CrossRefGoogle ScholarPubMed
Wilkins, A. J., Binnie, C. D., Darby, C. E. (1980) Visuallyinduced seizures. Progress in Neurobiology 15: 15–85.CrossRefGoogle ScholarPubMed
Wilkins, A., Nimmo-Smith, I., Tait, A., McManus, C., Della Sala, S., Tilley, A., Arnold, K., Barrie, M., Scott, S. (1984) A neurological basis for visual discomfort. Brain 107: 107–989.CrossRefGoogle ScholarPubMed
Wilson, W. M., Maughan, R. J. (1992) Evidence for a possible role of 5-HT in the genesis of fatigue in man - administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise. Experimental Physiology 79: 79–461.Google Scholar