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Iron deficiency is associated with poor prognosis in idiopathic sudden sensorineural hearing loss

Published online by Cambridge University Press:  29 April 2021

T Kurioka Open the ORCID record for T Kurioka [Opens in a new window] ,
H Sano Open the ORCID record for H Sano [Opens in a new window] ,
S Furuki Open the ORCID record for S Furuki [Opens in a new window]  and
T Yamashita Open the ORCID record for T Yamashita [Opens in a new window]
T Kurioka*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Kanagawa, Japan
H Sano
Affiliation:
School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
S Furuki
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Kanagawa, Japan
T Yamashita
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Kanagawa, Japan
*
Author for correspondence: Dr Takaomi Kurioka, Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, 1–15–1, Kitasato, Minami-ku, Sagamihara-shi, Kanagawa252-0374, Japan E-mail: [email protected] Fax: +81 42 778 8441
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Abstract

Objective

The effects of iron deficiency on the prognosis of idiopathic sudden sensorineural hearing loss are unclear. This study aimed to investigate the association between serum iron levels and idiopathic sudden sensorineural hearing loss prognosis and its usefulness as an independent prognostic marker for idiopathic sudden sensorineural hearing loss.

Methods

The audiological and haematological data, including hearing recovery and serum iron levels, of 103 patients with idiopathic sudden sensorineural hearing loss evaluated between 2015 and 2018 were retrospectively analysed.

Results

The overall complete recovery rate was 16.5 per cent. Initial higher hearing threshold was associated with poor idiopathic sudden sensorineural hearing loss prognosis. Serum iron levels were significantly higher in the complete recovery group than in the non-complete recovery group (p < 0.05).

Conclusion

The possibility of complete recovery from idiopathic sudden sensorineural hearing loss was significantly lower with lower serum iron levels, suggesting that the serum iron level might be a novel prognostic marker for idiopathic sudden sensorineural hearing loss.

Keywords

AnemiaIronPrognosisHearing Loss
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 6 , June 2021 , pp. 508 - 512
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr T Kurioka takes responsibility for the integrity of the content of the paper

References

Chang, YS, Park, S, Lee, MK, Rah, YC, Choi, J. Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. J Laryngol Otol 2020;134:419–23CrossRefGoogle ScholarPubMed
Attanasio, G, Russo, FY, Di Porto, E, Cagnoni, L, Masci, E, Ralli, M et al. Prediction of hearing recovery in sudden deafness treated with intratympanic steroids. Acta Otorhinolaryngol Ital 2018;38:453–9Google ScholarPubMed
Nonoyama, H, Tanigawa, T, Shibata, R, Nakao, Y, Horibe, Y, Katahira, N et al. Red blood cell distribution width predicts prognosis in idiopathic sudden sensorineural hearing loss. Acta Otolaryngol 2016;136:1137–40CrossRefGoogle ScholarPubMed
Beard, JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001;131:568S–79S; discussion 80SCrossRefGoogle ScholarPubMed
Henderson, D, Bielefeld, EC, Harris, KC, Hu, BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006;27:1–19CrossRefGoogle ScholarPubMed
Shi, X. Physiopathology of the cochlear microcirculation. Hear Res 2011;282:10–24CrossRefGoogle ScholarPubMed
Tabuchi, K, Nishimura, B, Tanaka, S, Hayashi, K, Hirose, Y, Hara, A. Ischemia-reperfusion injury of the cochlea: pharmacological strategies for cochlear protection and implications of glutamate and reactive oxygen species. Curr Neuropharmacol 2010;8:128–34CrossRefGoogle ScholarPubMed
Schieffer, KM, Chuang, CH, Connor, J, Pawelczyk, JA, Sekhar, DL. Iron deficiency anemia is associated with hearing loss in the adult population. JAMA Otolaryngol Head Neck Surg 2017;143:350–4CrossRefGoogle Scholar
Chung, SD, Chen, PY, Lin, HC, Hung, SH. Sudden sensorineural hearing loss associated with iron-deficiency anemia: a population-based study. JAMA Otolaryngol Head Neck Surg 2014;140:417–22CrossRefGoogle ScholarPubMed
Yanagita, N, Nakashima, T, Ohno, Y, Kanzaki, J, Shitara, T. Estimated annual number of patients treated for sensorineural hearing loss in Japan. Results of a nationwide epidemiological survey in 1987. Acta Otolaryngol Suppl 1994;514:9–13CrossRefGoogle ScholarPubMed
Kuhn, M, Heman-Ackah, SE, Shaikh, JA, Roehm, PC. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif 2011;15:91–105CrossRefGoogle Scholar
Hsu, YH, Hu, HY, Chiu, YC, Lee, FP, Huang, HM. Association of sudden sensorineural hearing loss with vertebrobasilar insufficiency. JAMA Otolaryngol Head Neck Surg 2016;142:672–5CrossRefGoogle ScholarPubMed
Kurioka, T, Matsunobu, T, Satoh, Y, Niwa, K, Shiotani, A. Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res 2014;89:69–74CrossRefGoogle ScholarPubMed
Belaidi, AA, Bush, AI. Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. J Neurochem 2016;139(suppl 1):179–97CrossRefGoogle ScholarPubMed
Castiglione, A, Ciorba, A, Aimoni, C, Orioli, E, Zeri, G, Vigliano, M et al. Sudden sensorineural hearing loss and polymorphisms in iron homeostasis genes: new insights from a case-control study. Biomed Res Int 2015;2015:834736CrossRefGoogle ScholarPubMed
Brissot, P, Ropert, M, Le Lan, C, Loreal, O. Non-transferrin bound iron: a key role in iron overload and iron toxicity. Biochim Biophys Acta 2012;1820:403–10CrossRefGoogle ScholarPubMed
Liu, X, Zheng, G, Wu, Y, Shen, X, Jing, J, Yu, T et al. Lead exposure results in hearing loss and disruption of the cochlear blood-labyrinth barrier and the protective role of iron supplement. Neurotoxicology 2013;39:173–81CrossRefGoogle ScholarPubMed