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Ipratropium bromide in the treatment of the ‘rhinorrhoea syndrome’

Published online by Cambridge University Press:  29 June 2007

T. P. O'Dwyer ,
R. J. Lee ,
J. Kaye  and
G. Fennell
T. P. O'Dwyer*
Affiliation:
Senior Registrar, Department of Otolaryngology, Eye & Ear Hospital, Dublin.
R. J. Lee
Affiliation:
Senior Registrar, Department of Otolaryngology, Federated Dublin Voluntary Hospitals.
J. Kaye
Affiliation:
Research Associate, Boehringer Ingelbeim Ltd., Bracknell.
G. Fennell
Affiliation:
Chief, Department of Otolaryngology, Eye & Ear Hospital, Dublin.
*
Mr. T. O'Dwyer, Royal Victoria Eye & Ear Hospital, Adelaide Road, Dublin 2, Ireland.
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Abstract

Conventional treatments for non-allergic perennial rhinitis have proven somewhat unsuccessful in the control of rhinorrhoea when it is the predominant symptom. Hence, a double-blind cross-over trial of Ipratropium, a parasympatholytic, and placebo were carried out over a 12-week period. There was a significant reduction in rhinorrhoea during active treatment, with the most noticable effect being in the moderate-to-severe rhinorrhoea group. No significant effect was noted on nasal obstruction or sneezing and no serious side-effects were seen. A carry-on effect was noted when active treatment was used initially. However, the group given active treatment following placebo had a better result overall. A strong placebo effect was also noted in both groups, in keeping with a trial of this order.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 9 , September 1988 , pp. 799 - 801
Copyright
Copyright © JLO (1984) Limited 1988

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References

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