Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-26T05:20:02.188Z Has data issue: false hasContentIssue false
  • English
  • Français

Invasive pituitary adenoma presenting with nasal obstruction

Published online by Cambridge University Press:  29 June 2007

J. A. Dent  and
P. K. Rickhuss
J. A. Dent*
Affiliation:
Lecturer, Department of Orthopaedic and Traumatic Surgery.
P. K. Rickhuss
Affiliation:
Registrar, Department of Plastic Surgery, Royal Infirmary, Dundee.
*
J. A. Dent, Lecturer, University Dept of Orthopaedic Surgery, Royal Infirmary, Dundee DD1 9ND.
Get access Rights & Permissions [Opens in a new window]

Abstract

We report two cases of massive invasive pituitary adenoma with the unusual presentation of nasal obstruction. In both cases the diagnosis was only made when the obstructing tissue was removed. Cases reported previously have usually presented with severe focal neurological signs or a long history of neurological symptoms. These two cases are unusual in having minimal neurological deficits despite the extension of tumour into the nasopharynx and the middle and posterior cranial fossae. These extensions were well illustrated by computerised tomography. This unusual presentation is discussed with reference to the literature.

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 6 , June 1989 , pp. 605 - 609
Copyright
Copyright © JLO (1984) Limited 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bailey, O. T. and Cutler, E. C. (1940) Malignant adenomas of the chromophobe cells of the pituitary body. Archives of Pathology, 29: 368–399.Google Scholar
Blaylock, R. L. and Kemp, L. G. (1977) Pituitary adenomas–a reappraisal of their pathology and treatment. Neurochirurgia, 20: 63–78.Google Scholar
Bouloux, P. M. (1988) Pituitary tumours. Surgery, 56: 1324–1329.Google Scholar
Cole, I. E. and Keene, M. (1981) Nasal obstruction in pituitary tumours. Journal of Laryngology and Otology, 95: 183–189.CrossRefGoogle ScholarPubMed
Fleischer, A. S., Reagan, T. and Ransohoff, J. (1972) Primary carcinoma of the pituitary with metastasis to the brain stem. Journal of Neurosurgery, 36: 781–784.CrossRefGoogle ScholarPubMed
Henderson, W. R. (1939) Pituitary adenomata; follow-up study of surgical results in 338 cases (Dr Harvey Cushings' series). British Journal of Surgery, 26: 811–921.CrossRefGoogle Scholar
Jefferson, G. (1940) Extrasellar extension of pituitary adenomas. Proceedings of the Royal Society of Medicine, 33: 433–458.CrossRefGoogle ScholarPubMed
Kay, S., Lees, J. K. and Stout, A. P. (1950) Pituitary chromophobe tumours of the nasal cavity. Cancer 3: 695–704.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Kojima, T., Waga, S. and Moroka, Y. (1980) Huge invasive pituitary adenoma with involvement of middle and posterior fossa. Neurolgia, Medico-Chirurgia (Tokyo) 20: 95–99.CrossRefGoogle ScholarPubMed
Lamberts, S. W. J., Uitterlinden, P. and Del Pozo, E. (1987) SMS 201–995 induces a continuous decline in circulating growth hormone and Somatomedin-C levels during therapy of acromegalic patients for over two years. Journal of Clinical Endocrinology and Metabolism, 65: 703–710.CrossRefGoogle ScholarPubMed
Lundberg, P. O., Drettner, B., Hemmingson, A., Steinkirst, B. and Wide, L. (1977) The invasive pituitary adenoma. Archives of Neurology, 34: 742–749.CrossRefGoogle ScholarPubMed
Mackay, A. and Hsosbuchi, Y. (1978) Treatment of intracavernous extensions of pituitary adenomas. Surgical Neurology, 10: 377–383.Google ScholarPubMed
Martins, A. N., Hayes, G. J. and Kempe, L. G. (1964) Invasive pituitary adenomas. Journal of Neurosurgery, 22: 268–276.CrossRefGoogle Scholar
Nutkiewicz, A., De Fes, D. T., Kohut, R. I. and Fierstien, S. (1980) Cerebrospinal fluid rhinorrhoea as a presentation of pituitary adenoma. Neurosurgery, 6: 195–197.Google ScholarPubMed
Rowe, P. W. and Jones, T. K. (1966) Malignant adenoma with extensive skull destruction. Radiology, 86: 532–534.CrossRefGoogle ScholarPubMed
Sammartino, A., Bonaiotonta, G., Pattinato, G. and Loffredo, A. (1979) Exophthalmos caused by an invasive pituitary adenoma in a child. Opthalmoligica, 179: 83–89.CrossRefGoogle ScholarPubMed
Shea, J. J. (1938) Cerebrospinal rhinorrhoea with autopsy report. Annals of Otology, Rhinology and Laryngology, 47: 253–260.CrossRefGoogle Scholar
Shea, J. J. (1941) Nasal tumours of pituitary origin (report of a case). Transactions of the American Laryngology, Rhinology, and Otology Society, 47: 201–203.Google Scholar
Summers, G. W. (1976) Nasal obstruction caused by a pituitary adenoma. Laryngoscope, 86: 1718–1721.CrossRefGoogle Scholar
White, J. C. and Warren, S. (1945) Unusual size and extension of a pituitary adenoma. Journal of Neurosurgery, 2: 126–139.CrossRefGoogle Scholar
Zorub, D. S., Martinex, A. J., Nelson, P. B. and Lam, M. T. (1979) Invasive pituitary adenoma with abscess formation: Case Report. Neurosurgery, 5: 718–722.CrossRefGoogle ScholarPubMed