Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-05T03:55:32.136Z Has data issue: false hasContentIssue false
  • English
  • Français

Intratympanic ototoxicity: influence of post-injection survival period

Published online by Cambridge University Press:  29 June 2007

M. W. Yung
M. W. Yung*
Affiliation:
Liverpool
*
M. W. Yung, Department of Otorhinolaryngology, University of Liverpool, P.O. Box 147, LiverpoolL69 3BX.
Get access Rights & Permissions [Opens in a new window]

Abstract

Many studies have been reported on the intratympanic ototoxicity of different drugs in animal models. The recovery periods of the animals following intratympanic drug applications varied among these studies. The present study compares the cochlear damage caused by intratympanic kanamycin following short (4 days) and long (30 days) post-injection survival periods, using the guinea pig as the animal model.

The degree of cochlear damage 4 days after kanamycin injection was consistent among the tested animals. The degeneration was mainly confined to the outer hair cells and almost all inner hair were spared. The change 30 days after kanamycin injection was more variable among the animals and both inner and outer hair cells were damaged. This shows that, although the damage to the cochlea after intratympanic aminoglycoside injection is progressive, a short post-injection recovery period is suitable for comparative intratympanic ototoxicity studies.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 10 , October 1987 , pp. 1011 - 1019
Copyright
Copyright © JLO (1984) Limited 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Akiyoshi, M. (1978) Evaluation of ototoxicity of tobramycin in guinea pigs. Journal of Antimicrobial Chemotherapy, 4 (Supplement A): 69–72.CrossRefGoogle ScholarPubMed
Aursnes, J. (1982) Ototoxic effect of quaternary ammonium compounds. Acta Otolaryngologica, 93: 421–433.CrossRefGoogle ScholarPubMed
Brummett, R. E., Harris, R. F. and Lindgren, J. A. (1976) Detection of ototoxicity from drugs applied topically to the middle ear space. Laryngoscope, 86: 1177–1187.CrossRefGoogle Scholar
Brummett, R. E., Fox, K. E., Bendrick, T. W. and Himes, D. L. (1978) Ototoxicity of tobramycin, gentamicin, amikacin and sisomicin in the guinea pig. Journal of Antimicrobial Chemotherapy, 4 (Supplement A): 73–78.CrossRefGoogle ScholarPubMed
Engström, H., Ades, H. W. and Hawkins, J. E. Jr. (1964) Cytoarchitecture of the organ of Corti. Acta Otolaryngologica (Stockholm), Supplement 188: 92–99.CrossRefGoogle Scholar
Hawkins, J. E. (1959) The ototoxicity of kanamycin. Annals of Otology, Rhinology and Laryngology, 68; 698–715.CrossRefGoogle ScholarPubMed
Kohonen, A. (1965) Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Otolaryngologica (Stockholm), Supplement 208.Google ScholarPubMed
Kohonen, A. and Tarkkanen, J. (1969) Cochlear damage from ototoxic antibiotics by intratympanic application. Acta Otolaryngologica (Stockholm), 68: 90–97.CrossRefGoogle ScholarPubMed
Rudnick, M. D., Ginsberg, I. A. and Huber, P. S. (1980) Aminoglycoside ototoxicity following middle ear injection. I. Experimental approach and histological criteria for evaluating drug effects. Annals of Otology, Rhinology and Laryngology, 89 (Supplement 77): 1–9.CrossRefGoogle Scholar
Schuknecht, H. F. (1957) Ablation therapy in the management of Meniere's Disease. Acta Otolaryngologica (Stockholm), Supplement 132.Google ScholarPubMed
Spoendlin, H. (1966) Zur Ototoxizitat des Streptomyzins. Practica Otorhinolaryngologica (Basel) 28: 305–322.Google Scholar
Stupp, H., Kupper, K., Lagler, F., Sous, H. and Quante, M. (1973) Inner ear concentrations and ototoxicity of different antibiotics in local and systemic application. Audiology, 12: 350–363.CrossRefGoogle ScholarPubMed
Webster, J. C, Carroll, R., Benitez, J. T. and McGee, T. M. (1971) Ototoxicity of topical gentamicin in the cat. Journal of Infectious Diseases, Supplement 124: S138.CrossRefGoogle ScholarPubMed
Yung, M. W. (1986a) Cochleotoxicity of amine group. Acta Otolaryngologica (Stockholm), 102: 365–371.CrossRefGoogle Scholar
Yung, M. W. (1986b) An improved morphological technique for cochleotoxicity study in guinea pigs. Journal of Laryngology and Otology, 100: 1235–1244.CrossRefGoogle ScholarPubMed