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Intratympanic gentamicin in Ménière's disease: our experience

Published online by Cambridge University Press:  15 February 2011

L Pérez Delgado ,
J Fraile Rodrigo  and
P Astier Peña
L Pérez Delgado*
Affiliation:
Otorhinolaryngology, Miguel Servet University Hospital, Zaragoza, Spain
J Fraile Rodrigo
Affiliation:
Otorhinolaryngology, Miguel Servet University Hospital, Zaragoza, Spain
P Astier Peña
Affiliation:
Family Medicine Services, Miguel Servet University Hospital, Zaragoza, Spain
*
Address for correspondence: Dr Laura Pérez Delgado, c/ Veracruz No 7, 2°B CP 50019, Zaragoza, Spain E-mail: [email protected]
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Abstract

Aims:

To analyse intratympanic gentamicin injection as a treatment option in patients with monolateral Ménière's disease resistant to medical treatment.

Material and methods:

Longitudinal, prospective, descriptive study of response to gentamicin treatment in 71 patients diagnosed with Ménière's disease and treated medically for more than a year, unsuccessfully. American Academy of Otolaryngology-Head and Neck Surgery criteria were used for diagnosis and follow up.

Results:

Complete vertigo control was obtained in 65.6 per cent of patients, and complete or substantial control in 84.37 per cent. Thirteen patients (18.3 per cent) suffered significant hearing loss.

Conclusion:

This intratympanic gentamicin injection protocol enabled effective vertigo control in most patients, and represents a good alternative to more aggressive techniques for the treatment of Ménière's disease which does not respond to medical treatment.

Keywords

VertigoGentamicinTherapeuticsEar, Middle
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 4 , April 2011 , pp. 363 - 369
Copyright
Copyright © JLO (1984) Limited 2011

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