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The inhibitory effects of TNP470 on tumour growth of head and neck carcinoma cell producing interleukin-8

Published online by Cambridge University Press:  08 March 2006

Toshirou Kawano ,
Shunsuke Yanoma ,
Goshi Nishimura  and
Mamoru Tsukuda
Toshirou Kawano
Affiliation:
Research Institute, Kanagawa Cancer Center, Yokohama, Japan
Shunsuke Yanoma
Affiliation:
Research Institute, Kanagawa Cancer Center, Yokohama, Japan
Goshi Nishimura
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Japan
Mamoru Tsukuda
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Japan
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Abstract

The anti-tumour effect of the angiogenic inhibitor TNP470, σ-(chloro-acetyl-carbamoyl) fumagillol, a synthetic analogue of fumagillin, was studied in vitro and in vivo using KB cells, one of the human head and neck carcinoma cell lines that produce interleukin(IL)-8. In the in vitro study, the combination treatment of TNP470 and anti-IL-8 antibody significantly reduced the proliferation of KB cells. In the in vivo studies, TNP470 administration by any route (intratumoral: it, intraperitoneal: ip, intravenous: iv) reduced the tumour volume significantly, compared to the control group. Among the groups administered TNP470, the anti-tumour effect was strongest in the it group. Furthermore, the concurrent treatment of anti-IL-8 antibody and TNP470 also maximally reduced the tumour volume. The combination therapy of TNP470 and anti-IL-8 antibody was very effective. These results suggest that combination therapy of TNP470 and anti-IL-8 antibody could be beneficial for solid tumours, such as head and neck cancer.

Keywords

Angiogenesis InhibitorsHead and Neck NeoplasmsCarcinoma, Squamous CellInterleukin 8
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 115 , Issue 10 , October 2001 , pp. 802 - 807
Copyright
© Royal Society of Medicine Press Limited 2001

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