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Influence of anaesthetic agents on transient evoked otoacoustic emissions and stapedius reflex thresholds

Published online by Cambridge University Press:  25 November 2005

Selis Guven ,
Abdullah Tas ,
Mustafa K Adali ,
Recep Yagiz ,
Cem Uzun ,
Muhsin Koten  and
Ahmet R Karasalihoglu
Selis Guven
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
Abdullah Tas
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
Mustafa K Adali
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
Recep Yagiz
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
Cem Uzun
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
Muhsin Koten
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
Ahmet R Karasalihoglu
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Trakya University, Edirne, Turkey
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Abstract

This aim of this study was to determine the effect of anaesthetic agents on stapedius reflex (SR) thresholds and transient evoked otoacoustic emissions (TEOAE). Fifty patients who were scheduled for operation and who had normal hearing were included in the study. All were given midazolam for premedication and propofol for induction. Anaesthesia was maintained in five different ways in each group of 10 patients. Groups I–IV received inhalational anaesthesia: group I received 70 per cent N2O plus 30 per cent O2, group II sevoflurane, group III desflurane and group IV halothane. Group V received total intravenous anaesthesia with propofol plus sufentanil. The SR and TEOAE of the patients were measured four times: on the day before surgery (first measurement), after premedication (second measurement), after induction of anaesthesia (third measurement) and during maintenance of anaesthesia (fourth measurement). Midazolam significantly increased ipsilateral and contralateral SR thresholds and decreased TEOAE wave reproducibility. Propofol significantly increased only the SR thresholds. The other anaesthetic agents significantly increased only the contralateral reflex thresholds. Of these, the highest increase was seen after sevoflurane and the lowest after halothane. The changes in TEOAE wave reproducibility due to anaesthetic agents used for maintenance were not significant. We concluded that midazolam premedication may affect audiological evaluation with SR and TEOAE tests, and sevoflurane should not be used when it is necessary to measure SR under general anaesthesia.

Keywords

Otoacoustic EmissionsSpontaneousReflexAcousticAnaestheticsGeneralHalothanePropofol
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 1 , January 2006 , pp. 10 - 15
Copyright
2005 JLO (1984) Limited

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