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Impact of pre-operative body mass index in head and neck cancer patients undergoing microvascular reconstruction

Published online by Cambridge University Press:  02 October 2017

D-J Hyun ,
Y-H Joo  and
M-S Kim
D-J Hyun
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, GNG Hospital, Seoul, Republic of Korea
Y-H Joo
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
M-S Kim*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
*
Address for correspondence: Dr Min-Sik Kim, Department of Otolaryngology – Head and Neck Surgery, 505 Banpodong Seochogu, Seoul St Mary's Hospital, Catholic University of Korea, Seoul 137-040, Republic of Korea E-mail: [email protected]
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Abstract

Objectives:

To analyse the relationship of pre-operative body mass index with surgical complications and oncological outcomes in patients undergoing microvascular reconstruction for head and neck squamous cell cancer.

Method:

A retrospective review was conducted of 259 patients who underwent microvascular free flap reconstruction after head and neck ablative surgery.

Results:

Mean body mass index was 22.48 kg/m2. There were no correlations between body mass index and: flap failure (p = 0.739), flap ischaemia (p = 0.644), pharyngocutaneous fistula (p = 0.141) or wound infection (p = 0.224). The five-year disease-specific survival rate was 63 per cent. On univariate analysis, the five-year disease-specific survival rate was significantly correlated with pre-operative body mass index, based on Kaplan–Meier survival curves (p = 0.028). The five-year disease-specific survival rates in underweight, normal weight, overweight and obese groups were 47 per cent, 55 per cent, 65 per cent and 80 per cent, respectively.

Conclusion:

Pre-operative body mass index was a useful predictor for recurrence and survival in patients who underwent microvascular reconstruction for head and neck squamous cell cancer.

Keywords

Squamous Cell CarcinomaHead And Neck NeoplasmsBody Mass IndexReconstructive Surgical ProcedureSurvival
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 11 , November 2017 , pp. 972 - 976
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Bui, DT, Cordeiro, PG, Hu, Q, Disa, JJ, Pusic, A, Mehrara, BJ. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps. Plast Reconstr Surg 2007;119:2092–100Google Scholar
2 Eckardt, A, Fokas, K. Microsurgical reconstruction in the head and neck region: an 18-year experience with 500 consecutive cases. J Craniomaxillofac Surg 2003;31:197–201 Google Scholar
3 Siegel, R, Naishadham, D, Jemal, A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10–29 CrossRefGoogle ScholarPubMed
4 WHO. Global Health Observatory (GHO) data. Overweight and obesity. In: http://www.who.int/gho/ncd/risk_factors/overweight/en/ [18 August 2017]Google Scholar
5 Renehan, AG, Tyson, M, Egger, M, Heller, RF, Zwahlen, M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008;371:569–78Google Scholar
6 Protani, M, Coory, M, Martin, JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat 2010;123:627–35Google Scholar
7 Gaudet, MM, Patel, AV, Sun, JZ, Hildebrand, JS, McCullough, ML, Chen, AY. Prospective studies of body mass index with head and neck cancer incidence and mortality. Cancer Epidemiol Biomarkers Prev 2012;21:497–503 Google Scholar
8 Deneuve, S, Tan, HK, Eghiaian, A, Temam, S. Management and outcome of head and neck squamous cell carcinomas in obese patients. Oral Oncol 2011;47:631–5CrossRefGoogle ScholarPubMed
9 McRackan, TR, Watkins, JM, Herrin, AE, Garrett-Mayer, EM, Sharma, AK, Day, TA et al. Effect of body mass index on chemoradiation outcomes in head and neck cancer. Laryngoscope 2008;118:1180–5Google Scholar
10 WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157–63Google Scholar
11 Liu, W, Wahafu, T, Cheng, M, Cheng, T, Zhang, Y, Zhang, X. The influence of obesity on primary total hip arthroplasty outcomes: a meta-analysis of prospective cohort studies. Orthop Traumatol Surg Res 2015;101:289–96Google Scholar
12 McDermott, FD, Heeney, A, Kelly, ME, Steele, RJ, Carlson, GL, Winter, DC. Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg 2015;102:462–79Google Scholar
13 de la Garza, G, Militsakh, O, Panwar, A, Galloway, TL, Jorgensen, JB, Ledgerwood, LG et al. Obesity and perioperative complications in head and neck free tissue reconstruction. Head Neck 2016;38(suppl 1):E1188–91Google Scholar
14 Hollander, Dd, Kampman, E, van Herpen, CM. Pretreatment body mass index and head and neck cancer outcome: a review of the literature. Crit Rev Oncol Hematol 2015;96:328–38Google Scholar
15 Takenaka, Y, Takemoto, N, Nakahara, S, Yamamoto, Y, Yasui, T, Hanamoto, A et al. Prognostic significance of body mass index before treatment for head and neck cancer. Head Neck 2015;37:1518–23Google Scholar
16 Hakimi, AA, Furberg, H, Zabor, EC, Jacobsen, A, Schultz, N, Ciriello, G et al. An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst 2013;105:1862–70Google Scholar
17 Huang, PY, Wang, CT, Cao, KJ, Guo, X, Guo, L, Mo, HY et al. Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: findings from a randomised trial. Eur J Cancer 2013;49:1923–31CrossRefGoogle ScholarPubMed