Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-24T09:54:51.545Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunohistochemical findings of IgG recognized in the planum semilunatum of the guinea pig

Published online by Cambridge University Press:  29 June 2007

Minoru Ikeda  and
Claus Morgenstern
Minoru Ikeda*
Affiliation:
Department of Otolaryngology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Claus Morgenstern
Affiliation:
Department of Otolaryngology, Krankenhaus St. Georg, Hamburg, Germany.
*
Minoru Ikeda, M.D., Department of Otolargynology, Ninon University School of Medicine, 30-1 Oyaguchi, Itabashi-ku, Tokyo 173, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

The planum semilunatum is located on the lateral side of the crista ampullaris of thesemicircular canal. With regard to the functions of the planum semilunatum, some researchers assume the existence of secretory activity based on the microstructural features observed in isotopic experiments. In the present study, in order to confirm the existence of an immunological mechanism in the ampulla of the semicircular canal, the distribution of immunoglobulins in the semi-circular canal of guinea pigs was investigated immunohistochemically. Positivity of IgG wasobserved in the constituent cells of the planum semilunatum or beneath the basement membrane ofthe cells.It is concluded that ample IgG, which is an important constituent of the body fluids, is collected within this region. The planum semilunatum containing such ample amounts of IgG might be involved in the immunological mechanism operating in the ampullar of the semicircular canal.

Keywords

ImmunohistochemistryVestibuleGuinea pigs
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 2 , February 1992 , pp. 93 - 97
Copyright
Copyright © JLO (1984) Limited 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bairati, A. Jr., Iurato, S. (1960) The ultrastructural organization of ‘planum semilunata’. Experimental Cell Research, 20: 77–83.CrossRefGoogle Scholar
Curran, R. C., Gregory, J. (1980) Effects of fixation and processing on immunohistochemical demonstration of immunoglobulin in paraffin sections of tonsil and bone marrow. Journal of Clinical Pathology, 33: 1047–1057.CrossRefGoogle ScholarPubMed
Dohlman, G. (1965) The mechanism of secretion and absorption of endolymph in the vestibular apparatus. Acta Otolaryngologica, 59: 275–288.CrossRefGoogle Scholar
Dohlman, G., Ormerod, F. C., McLay, K. (1960) The secretory epithelium of the internal ear. Acta Otolaryngologica, 50: 243–249.CrossRefGoogle Scholar
Harada, Y. (1973) Scanning electron microscopic observation of vestibular specific cells. Pratica Otologica (Kyoto), 66: 1293–1300.CrossRefGoogle Scholar
Ikeda, M., Morgenstern, C. (1989) Immune response of the endolymphatic sac to horse-radish peroxidase: Immunologic route from the middle ear to the inner ear. Annals of Otology, Rhinology and Laryngology, 98: 975–979.Google Scholar
Kimura, R., Lundquist, P. G., Wersall, J. (1964) Secretory epithelial linings in the ampullae of the guinea pig labyrinth. Acta Otolaryngologica, 57: 517–530.CrossRefGoogle ScholarPubMed
Nomura, Y., Balogh, K. Jr. (1964) Metabolic pathways in the vestibular labyrinth as revealed by histochemical technics. Acta Otolaryngologica, 57: 484–492.CrossRefGoogle ScholarPubMed
Watanuki, K., Kawamoto, K., Katagiri, S. (1970) Surface structure of the ampulla of the semicircular canal in the guinea pig. Practica oto-rhino-laryngologica, 32: 137–148.Google ScholarPubMed