Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-24T09:43:00.515Z Has data issue: false hasContentIssue false
  • English
  • Français

Hypoparathyroidism after the treatment of laryngopharyngeal carcinoma

Published online by Cambridge University Press:  29 June 2007

S. Mortimore ,
M. A. Thorp ,
E. L. K. Nilssen  and
S. Isaacs
S. Mortimore*
Affiliation:
Department of Otolaryngology, Groote Schuur Hospital, Cape Town, South Africa
M. A. Thorp
Affiliation:
Department of Otolaryngology, Groote Schuur Hospital, Cape Town, South Africa
E. L. K. Nilssen
Affiliation:
Department of Otolaryngology, Groote Schuur Hospital, Cape Town, South Africa
S. Isaacs
Affiliation:
Medical Informatics Department, Groote Schuur Hospital, Cape Town, South Africa
*
Address for correspondence: Mr S. Mortimore, Department of Otorhinolaryngology, Royal Liverpool University Hospital, Daulby Street, Liverpool, L69 3GA
Get access Rights & Permissions [Opens in a new window]

Abstract

Thirty patients with squamous cell carcinoma of the laryngopharynx were treated with surgery (total laryngectomy and hemithyroidectomy) and radiotherapy. Group 1 (n = 7) patients had surgery only; Group 2 (n = 7) had radiotherapy followed by salvage surgery while Group 3 (n = 16) had surgery followed by radiotherapy.

Parathyroid hormone and calcium levels were measured pre- and post-operatively and pdstradiotherapy. In Group 1 no patients were hypoparathyroid. In Group 2, 29 per cent of patients preoperatively and 57 per cent post-operatively, were hypoparathyroid. In Group 3, no patients were hypoparathyroid pre-operatively, while 25 per cent were hypoparathyroid post-operatively and postradiotherapy. Parathyroid honnone and calcium levels were averaged and compared within and between each group. There was no significant difference within each group, when comparing levels postoperatively and post-radiotherapy from those of pre-operatively. There was no significant difference in levels between each of Groups 1, 2 or 3 (p>0.05).

Keywords

Hypoparathyroidism, Radiotherapy, Surgery, operativeLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 11 , November 1998 , pp. 1058 - 1060
Copyright
Copyright © JLO (1984) Limited 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented at the 1996 Combined 3rd Scientific Meeting of the Pan African Federation of Otolaryngological Societies and the 32nd Annual Academic Meeting of the South African Society of Otorhinolaryngology, Head and Neck Surgery Congress.

References

Bellamy, R. J., Kendall-Taylor, P. (1995) Unrecognized hypocalcaemia 36 years after thyroidectomy. Journal of the Royal Society of Medicine 88: 690–691.CrossRefGoogle ScholarPubMed
Buchanan, G., West, T. E. T., Woodhead, J. S., Lowy, C. (1975) Hypoparathyroidism following pharyngolaryngooesophagectomy. Clinical Oncology 1: 89–96.Google ScholarPubMed
Fink, A., Hays, A. D., Moore, A. A., Beck, J. C. (1996) Alcohol-related problems in older persons. Determinants, consequences, and screening. Archives of Internal Medicine 156(11): 1150–1156.Google Scholar
Fujiwara, S., Sposto, R., Shiraki, M., Yokoyama, N., Sasaki, H., Kodama, K., Shimaoka, (1994) Levels of parathyroid hormone and calcitonin in serum among atomic bomb survivors. Radiation Research 137: 96–103.Google Scholar
Graham, S. (1981) Dietary factors in the epidemiology of cancer of the larynx. American Journal of Epidemiology 113: 675–680.Google Scholar
Gregor, R. T. (1997) Total laryngectomy. In Operative Otorhinolaryngology (Bleach, N., Milford, C., Van Hasselt, A., eds.) Blackwell Science, Oxford, pp 365–372.Google Scholar
Hancock, S. L., Cox, R. S., Ross McDougall, I. (1991) Thyroid disease after treatment of Hodgkin's disease. New England Journal of Medicine 325: 599–605.CrossRefGoogle ScholarPubMed
Hermans, C., Lefebvre, C., Devolelaer, J.-P., Lambert, M. (1996) Hypocalcaemia and chronic alcohol intoxication: transient hypoparathyroidism secondary to magnesium deficiency. Clinical Rheumatology 15(2): 193–196.Google Scholar
Isaacson, S. R. (1980) Hypocalcaemia in surgery for carcinoma of the pharynx and larynx. Otolaryngologic Clinics of North America 13(1): 181–192.CrossRefGoogle Scholar
Isaacson, S. R., Lowry, L. D.. Snow, J. B. (1977) Hypoparathyroidism secondary to surgery for carcinoma of the pharynx and larynx. Transatlantic American Academy of Ophthalmology and Otolaryngology 84: 584–590.Google ScholarPubMed
Krespi, Y. P., Wurster, C. F., Wang, T. D., Stone, D. M. (1985) Hypoparathyroidism following total laryngopharyngectomy and gastric pull-up. Laryngoscope 95: 1184–1187.Google Scholar
Kudoh, C., Tanaka, S., Marusaki, S., Takahashi, N., Miyazaki, Y., Yoshioka, N., Hayashi, M., Shimamoto, K., Kikuchi, K., Iimura, O. (1992) Hypocalcaemic cardiomyopathy in a patient with idiopathic hypoparathyroidism. Internal Medicine 31(4): 561–568.Google Scholar
Ledger, G. A. (1994) Hypocalcaemia and hypoparathyroidism. Current Therapy in Endocrinology and Metabolism 5: 508–510.Google ScholarPubMed
Laehman, J. B., Leidy, J. W. Jr (1994) A post-thryoidectomy convulsion: an unusual presentation of chronic hypoparathyroidism. West Virginia Medical Journal 90(10): 420–421.Google Scholar
Osborne, D. A., Jones, W. I. (1968) Parathyroid dysfunction following surgery of the pharynx and larynx. British Journal of Surgery 55: 277–282.Google Scholar
Sasaki, C. T., Carlson, R. D. (1993) Malignant neoplasms of the larynx. In Otolaryngology – Head and Neck Surgery 2nd Edition (Cummings, C. W., Fredrickson, J. M., Harker, L. A., Krause, C. J., Schuller, D. E., eds.) Mosby-Wolfe, Baltimore, pp 1925–1954.Google Scholar
Stell, P. M., Maran, A. G. D. (1993) Tumours of the larynx. In Stell and Maran's Head and Neck Surgery 3rd Edition (Maran, A. G. D., Gaze, M., Wilson, J. A., eds.), Butterworth-Heinmann, Oxford, pp 153–179.Google Scholar
Van Middlesworth, L. (1993) Thyroid/parathyroid physiology. In Otolaryngology – Head and Neck Surgery. 2nd Edition. (Cummings, C. W., Fredrickson, J. M., Harker, L. A., Krause, C. J., Schuller, D. E., eds.), pp 2408–2413.Google Scholar