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Hyponatraemia and hypothyroidism in a previously irradiated case of carcinoma of the tongue

Published online by Cambridge University Press:  29 June 2007

N. A. Nasser  and
E. G. Lever
N. A. Nasser*
Affiliation:
Senior Registrar, Department of Oral and Maxillofacial Surgery, King's College Hospital, Denmark Hill, London, SE5 8RX.
E. G. Lever
Affiliation:
Senior Registrar, Department of Medicine, King's College Hospital, Denmark Hill, London, SE5 8RX.
*
N. A. Nasser, F.D.S. F.R.C.S. (Eng). Senior Registrar, Dept. Oral and Maxillo-facial Surgery, King's College Hospital Dental School, Denmark Hill, London SE5 8RX.
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Abstract

A case of squamous cell carcinoma of the tongue was complicated by post operative hyponatraemia. The criteria for the syndrome of inappropriate secretion of anti diuretic hormone, [ADH] (SIADH) were met but the patient remained hyponatraemic despite adequate treatment. The patient had previously received radical external radiotherapy to the neck and was found to be profoundly hypothyroid. Correction of the hypothyroid state led to clinical and biochemical recovery. The frequency of post-irradiation hypothyroidism and the possible mechanisms of hypothyroid-induced hyponatraemia are discussed

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 7 , July 1987 , pp. 685 - 688
Copyright
Copyright © JLO (1984) Limited 1987

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References

Bartter, F. C. and Schwartz, W. B. (1967) The syndrome of inappropriate secretion of antidiuretic hormone. American Journal of Medicine, 42: 790–806.CrossRefGoogle ScholarPubMed
Brones, M. F., Kawamoto, H. K. Jr and Renaudin, J. (1982) Inappropriate antidiuretic hormone syndrome in craniofacial surgery. Journal of Plastic and Reconstructive Surgery, 71: 1–3.Google Scholar
Discala, V. A. and Kinney, M. J. (1971) Effects of myxedema on the renal diluting and concentrating mechanism. American Journal of Medicine, 50: 325–335.CrossRefGoogle ScholarPubMed
Felix, H., Dupre, N., Drape, M. and Court, L. (1961) Lyons Medical Journal, 206: 1043.Google Scholar
Forrest, J. N. Jr, Cox, M., Hong, C., Morrison, G., Bia, M., and Singer, I. (1978) Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of anti-diuretic hormone. New England Journal of Medicine. 298: 173–177.CrossRefGoogle Scholar
Groover, T. A., Christie, A. C., Merritt, E. A., Coe, F. O. and McPeak, E. M. (1929) Journal American Medicine Association, 92: 1730.CrossRefGoogle Scholar
Jamieson, M. J. (1985) Clinical Algorithm: Hyponatraemia. British Medical Journal, 290: 1723–1728.CrossRefGoogle Scholar
Kaplan, M. M., Garnick, M. B.Gelber, R., Li, F. P., Cassady, J. R., Sallan, S. E., Fine, W. E. and Sack, M. J. (1983) Risk factors for thyroid abnormalities after neck irradiation for childhood cancer. American Journal of Medicine, 74: 272–280.CrossRefGoogle ScholarPubMed
Markson, J. L. and Flatman, G. E. (1965) Myxoedema after Deep X-ray Therapy to the Neck. British Medical Journal, 1: 1228–1230.CrossRefGoogle ScholarPubMed
Nelson, D. F.Reddy, K. V., O'Mary, R. E. and Rubin, P. (1978) Thyroid abnormalities following neck irradiation for Hodgkin's disease. Cancer, 42: 2553–2562.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Pettinger, W. A., Talner, L. and Ferries, (1965) Inappropriate secretion of antidiuretic hormone due to myxoedema. New England Journal of Medicine. 272: 362–364.CrossRefGoogle Scholar
Prager, D. and Sembrot, J. T. (1972) Cobalt-60 therapy of Hodgkin's disease and the subsequent development of hypothyroidism. Cancer, 29: 458–460.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Tamura, K., Shimaoka, K. and Friedman, M. (1981) Thyroid abnormalities associated with treatment of malignant lymphoma. Cancer, 47: 2704–2711.3.0.CO;2-G>CrossRefGoogle ScholarPubMed