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Graves' disease, with and without nodules, and the risk of thyroid carcinoma

Published online by Cambridge University Press:  15 August 2007

Y Erbil ,
U Barbaros ,
N Özbey ,
Y Kapran ,
M Tükenmez ,
A Bozbora  and
S Özarmağan
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Abstract

Objective:

Thyroid nodules are frequently present in Graves' disease. The aim of this study was to evaluate the risk of thyroid carcinoma in Graves' disease patients, with and without ultrasonographically identified nodules, who subsequently underwent surgical treatment.

Design:

The study group included 150 consecutive patients with diagnosed Graves' disease who subsequently underwent surgery.

Subjects:

The patients were divided into two groups according to whether the pre-operative ultrasound scan showed diffuse parenchyma (group one; n = 70) or nodules (group two; n = 80).

Results:

Of the 150 patients, 18 (12 per cent) were found to have papillary thyroid carcinoma. Papillary carcinoma was found in seven patients (10 per cent) in group one and in 11 patients (1.7 per cent) in group two. After evaluating the overall groups, the incidence of carcinoma in the parenchyma outside a nodule was 67 per cent, whereas the incidence of carcinoma in a nodule was 33 per cent.

Conclusion:

Carcinoma can occur in Graves' disease patients without nodules, and the absence of nodules on ultrasonographic examination does not reduce the risk of malignancy.

Keywords

Thyroid NeoplasmsGraves'DiseasePapillary CarcinomaSonography
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 3 , March 2008 , pp. 291 - 295
Copyright
Copyright © JLO (1984) Limited 2007

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References

1 Belfiore, A, Russo, D, Vigneri, R, Filetti, S. Graves' disease, thyroid nodules and thyroid carcinoma. Clin Endocrinol 2001;55:711–1810.1046/j.1365-2265.2001.01415.xCrossRefGoogle Scholar
2 Carnell, NE, Valente, WA. Thyroid nodules in Graves' disease: classification, characterization, and response to treatment. Thyroid 1988;8:571–610.1089/thy.1998.8.571CrossRefGoogle Scholar
3 Kraimps, JL, Bouin-Pineau, MH, Mathonnet, M, De Calan, L, Ronceray, J, Visset, J et al. Multicentre study of thyroid nodules in patients with Graves' disease. Br J Surg 2000;87:1111–1310.1046/j.1365-2168.2000.01504.xCrossRefGoogle ScholarPubMed
4 Mishra, A, Mishra, S. Thyroid nodules in Graves' disease: implications in an endemically iodine deficient area. J Postgrad Med 2001;47:244–7Google Scholar
5 Silver, RJ, Parangi, S. Management of thyroid incidentalomas. Surg Clin North Am 2004;84:907–20CrossRefGoogle ScholarPubMed
6 Cantalamessa, L, Baldini, M, Orsatti, A, Meroni, L, Amodei, V, Castagnone, D. Thyroid nodules in Graves disease and the risk of thyroid carcinoma. Arch Intern Med 1999;159:1705–8CrossRefGoogle ScholarPubMed
7 Chao, TC, Lin, JD, Jeng, LB, Chen, MF. Thyroid carcinoma with concurrent hyperthyroidism. Arch Surg 1999;134:130–4CrossRefGoogle ScholarPubMed
8 Gerenova, J, Buysschaert, M, Burbure, CY, Daumerie, C. Prevalence of thyroid carcinoma in Graves' disease: a retrospective study a cohort of 103 patients treated surgically. Eur J Intern Med 2003;14:321–510.1016/S0953-6205(03)00105-5CrossRefGoogle ScholarPubMed
9 Mazzeferri, EL. Thyroid carcinoma and Graves's disease. J Clin Endocrinol Metab 1990;70:826–9Google Scholar
10 Okamoto, T, Iihara, M, Obara, T. Management of hyperthyroidism due to Graves' and nodular diseases. World J Surg 2000;24:957–6110.1007/s002680010167CrossRefGoogle ScholarPubMed
11 Terzioğlu, T, Tezelman, S, Onaran, Y, Tanakol, R. Concurrent hyperthyroidism and thyroid carcinoma. Br J Surg 1993;80:1301–210.1002/bjs.1800801027CrossRefGoogle ScholarPubMed
12 Brander, A, Viikinkoski, P, Nickels, J, Kivisaari, L. Thyroid gland: US screening in a random adult population. Radiology 1991;181:683–710.1148/radiology.181.3.1947082CrossRefGoogle Scholar
13 Komorowski, RA, Hanson, GA. Occult thyroid pathology in the young adult: an autopsy study of 138 patients without clinical thyroid disease. Hum Pathol 1988;19:689–96CrossRefGoogle Scholar
14 Sampson, RJ, Woolner, LB, Bahn, RC, Kurland, LT. Occult thyroid carcinoma in Olmsted Country, Minnesota: prevalence at autopsy compared with that in Hiroshima and Nagasaki, Japan. Carcinoma 1974;34:2072–6Google Scholar
15 Giles, Y, Boztepe, H, Terzioğlu, T, Tezelman, S. The advantage of total thyroidectomy to avoid reoperation for incidental thyroid carcinoma in multinodular goiter. Arch Surg 2004;139:179–8210.1001/archsurg.139.2.179CrossRefGoogle ScholarPubMed
16 Ringel, MD, Ladenson, PW. Controversies in the follow-up and management of well-differentiated thyroid carcinoma. Endocrine-Related Carcinoma 2004;11:97–116CrossRefGoogle Scholar
17 Pellegriti, G, Scollo, C, Lumera, G, Regalbuto, C, Vigneri, R, Belfiore, A. Clinical behavior and outcome of papillary thyroid carcinomas smaller than 1.5 cm in diameter: study of 299 cases. J Clin Endocrinol Metab 2004;89:3713–20CrossRefGoogle ScholarPubMed
18 Belfiore, A, Garofalo, MR, Giuffrida, D, Runello, F, Filetti, S, Fiumara, A et al. Increased aggressiveness of thyroid carcinoma in patients with Graves' disease. J Clin Endocrinol Metab 1990;70:830–5CrossRefGoogle ScholarPubMed
19 Hales, IB, McElduff, A, Crummer, P, Clifton-Bligh, P, Delbridge, L, Hoschl, R et al. Does Graves' disease or thyrotoxicosis affect prognosis of thyroid carcinoma. J Clin Endocrinol Metab 1992;75:886–9Google ScholarPubMed