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Gentamicin administration via peritoneal dialysis fluid: the risk of ototoxicity

Published online by Cambridge University Press:  29 June 2007

B. S. Gendeh ,
H. Said ,
A. G. Gibb ,
N. S. Aziz  and
Z. M. Zahir
B. S. Gendeh
Affiliation:
Kuala Lumpur, Malaysia
H. Said*
Affiliation:
Kuala Lumpur, Malaysia
A. G. Gibb
Affiliation:
Kuala Lumpur, Malaysia
N. S. Aziz
Affiliation:
Kuala Lumpur, Malaysia
Z. M. Zahir
Affiliation:
Kuala Lumpur, Malaysia
*
H. Said, F.R.C.S.Ed., F.R.C.S. Glas., Associate Professor and Head of ENT Department, Faculty of Medicine, National University of Malaysia (U.K.M.), Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur.
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Abstract

In a prospective study on 47 patients, 16 mg of gentamicin per two litres dialysate was administered intraperitoneally at every cycle of intermittent peritoneal dialysis, carried out over the course of several days. Serum gentamicin sampling, pure tone audiometry and caloric tests were performed before and during the treatment. The gentamicin levels reached at the end of the thirtieth cycle were observed to be low. In view of this, the risk of acute ototoxicity was considered to be minimal. This was confirmed by the absence of clinical audiometric or vestibulometric evidence of toxicity.

Keywords

OtoxicityGentamicinDialysisperitoneal
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 12 , December 1991 , pp. 999 - 1001
Copyright
Copyright © JLO (1984) Limited 1991

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Footnotes

Paper presented at Fourth ASEAN, Otorhinolaryngological and Head and Neck Congress Organised by the Academy of Medicine, Singapore, April, 1989.

References

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