Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-04T20:26:46.012Z Has data issue: false hasContentIssue false
  • English
  • Français

Gamma-aminobutyric acid concentrations in benign parotid tumours and unstimulated parotid saliva

Published online by Cambridge University Press:  17 December 2010

E Jezewska ,
A Scinska ,
W Kukwa ,
A Sobolewska ,
D Turzynska ,
J Samochowiec  and
P Bienkowski
E Jezewska
Affiliation:
Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland Consultant Otolaryngologist Unit, Institute of Psychiatry and Neurology, Warsaw, Poland
A Scinska
Affiliation:
Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland Consultant Otolaryngologist Unit, Institute of Psychiatry and Neurology, Warsaw, Poland
W Kukwa
Affiliation:
Department of Otolaryngology, Czerniakowski Hospital, Warsaw Medical University, Warsaw, Poland
A Sobolewska
Affiliation:
Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
D Turzynska
Affiliation:
Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
J Samochowiec
Affiliation:
Department of Psychiatry, Pomeranian Medical Academy, Szczecin, Poland
P Bienkowski*
Affiliation:
Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland
*
Address for correspondence: Dr Przemyslaw Bienkowski, Department of Pharmacology, Institute of Psychiatry and Neurology, 9 Sobieskiego St, 02-957 Warsaw, Poland Fax: +48 22 84 27 644 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Apart from its role as an inhibitory neurotransmitter, γ-aminobutyric acid is also thought to regulate various stages of cell proliferation and differentiation in the brain and periphery. The present study aimed to assess the levels of γ-aminobutyric acid and its biochemical precursor glutamic acid (glutamate) in benign parotid tumours and in unstimulated parotid saliva.

Method:

Unstimulated parotid saliva was collected bilaterally, using the swab method, in 20 patients with unilateral pleomorphic adenoma or Warthin's tumour. Samples of tumour and adjacent salivary tissue were collected during tumour resection.

Results:

Concentrations of γ-aminobutyric acid and glutamate, but not aspartate, were significantly higher in the tumour tissue than in the non-tumour tissue. There was no significant difference in salivary concentrations of γ-aminobutyric acid, glutamate or aspartate, comparing the involved and non-involved side.

Conclusion:

The present results provide preliminary evidence that γ-aminobutyric acid may be involved in the growth of benign parotid tumours.

Keywords

Parotid NeoplasmsSalivaGamma-Aminobutyric acid
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 5 , May 2011 , pp. 492 - 496
Copyright
Copyright © JLO (1984) Limited 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Watanabe, M, Maemura, K, Kanbara, K. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol 2002;213:1–47Google Scholar
2Tillakaratne, NJK, Medina-Kauwe, L, Gibson, KM. γ-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem Physiol 1995;112:247–63Google Scholar
3Bormann, J. The ‘ABC’ of GABA receptors. Trends Pharmacol Sci 2000;21:16–9Google Scholar
4Watanabe, M, Maemura, K, Oki, K, Shiraishi, N, Shibayama, Y, Katsu, K. γ-aminobutyric acid (GABA) and cell proliferation: focus on cancer cells. Histol Histopathol 2006;21:1135–41Google ScholarPubMed
5Ge, S, Pradhan, DA, Ming, G-L, Song, H. GABA sets the tempo for activity-dependent adult neurogenesis. Trends Neurosci 2007;30:1–8CrossRefGoogle ScholarPubMed
6Ortega, A. A new role for GABA: inhibition of tumor cell migration. Trends Pharmacol Sci 2003;24:151–4CrossRefGoogle ScholarPubMed
7Andäng, M, Hjerling-Leffler, J, Moliner, A, Lundgren, TK, Castelo-Branco, G, Nanou, E et al. Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation. Nature 2008;451:460–4Google Scholar
8Young, SZ, Bordey, A. GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches. Physiology 2009;24:171–85Google Scholar
9Andersson, AC, Henningsson, S, Jarhult, J. Diamine oxidase activity and γ-aminobutyric acid formation in medullary carcinoma of the thyroid. Agents Action 1980;10:299–301CrossRefGoogle ScholarPubMed
10Kleinrok, Z, Matuszek, M, Jesipowicz, J, Matuszek, A, Opolski, A, Radzikowski, C. GABA content and GAD activity in colon tumors taken from patients with colon cancer or from xenografted human colon cancer cells growing as s.c. tumors in athymic nu/nu mice. J Physiol Pharmacol 1998;49:303–10Google Scholar
11Maemura, K, Yamauchi, H, Hayasaki, H, Kanbara, K, Tamayama, T, Hirata, I et al. γ-amino-butyric acid immunoreactivity in intramucosal colonic tumors. J Gastroenterol Hepatol 2003;18:1089–94Google Scholar
12Mazurkiewicz, M, Opolski, A, Wietrzyk, J, Radzikowski, C, Kleinrok, Z. GABA level and GAD activity in human and mouse normal and neoplastic mammary gland. J Exp Clin Cancer Res 1999;18:247–53Google ScholarPubMed
13Tatsuta, M, Iishi, H, Baba, M, Nakaizumi, A, Ichii, M, Taniguchi, H. Inhibition by γ-amino-n-butyric acid and baclofen of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res 1990;50:4931–4Google ScholarPubMed
14Tatsuta, M, Iishi, H, Baba, M, Taniguchi, H. Attenuation by the GABA receptor agonist baclofen of experimental carcinogenesis in the rat colon by azoxymethane. Oncology 1992;49:241–5CrossRefGoogle ScholarPubMed
15Nicholson-Guthrie, CS, Guthrie, GD, Sutton, GP, Baenziger, JC. Urine GABA levels in ovarian cancer patients: elevated GABA in malignancy. Cancer Lett 2001;162:27–30Google Scholar
16Ansari, MH. Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg 2007;65:2187–94CrossRefGoogle Scholar
17Lee, KJ. Essential Otolaryngology. Connecticut, USA: Stamford, Appleton & Lange, 1995Google Scholar
18Madani, G, Beale, T. Tumors of the salivary glands. Semin Ultrasound CT MRI 2006;27:452–64CrossRefGoogle ScholarPubMed
19Sawaki, K, Ouchi, K, Sato, T, Kawaguchi, M. Existence of γ-aminobutyric acid and its biosynthetic and metabolic enzymes in rat salivary gland. Jpn J Pharmacol 1995;67:359–63Google Scholar
20Jezewska, E, Scinska, A, Kukwa, W, Bienkowski, P. Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland. Auris Nasus Larynx 2009;36:586–9Google Scholar
21Sreebny, LM. Saliva in health and disease: an appraisal and update. Int Dent J 2000;50:140–61Google Scholar
22Ahlner, BH, Lind, MG. A swab technique for sialometry. Acta Otolaryngol 1983;95:173–82Google Scholar
23Scinska-Bienkowska, A, Wrobel, E, Turzynska, D, Bidzinski, A, Jezewska, E, Sienkiewicz-Jarosz, H et al. Glutamate concentration in whole saliva and taste responses to monosodium glutamate in humans. Nutr Neurosci 2006;9:25–31CrossRefGoogle ScholarPubMed
24Maciejak, P, Czlonkowska, AI, Bidzinski, A, Walkowiak, J, Szyndler, J, Lehner, M et al. Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine. Pharmacol Biochem Behav 2004;78:781–6Google Scholar
25Okada, Y, Taniguchi, H, Schimada, C. High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma. Science 1976;194:620–2Google Scholar
26Hinoi, E, Takarada, T, Ueshima, T, Tsuchihashi, Y, Yoneda, Y. Glutamate signaling in peripheral tissues. Eur J Biochem 2004;271:1–13Google Scholar