Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-28T21:15:54.090Z Has data issue: false hasContentIssue false
  • English
  • Français

Functional outcomes of early laryngeal cancer – endoscopic laser surgery versus external beam radiotherapy: a systematic review

Published online by Cambridge University Press:  13 October 2021

K Boyle Open the ORCID record for K Boyle [Opens in a new window]  and
S Jones
K Boyle*
Affiliation:
Emergency Department, Royal Adelaide Hospital, Adelaide, Australia
S Jones
Affiliation:
Otorhinolaryngology Department, Ninewells Hospital, Dundee, Scotland, UK
*
Author for correspondence: Dr K Boyle, Emergency Department, Royal Adelaide Hospital, Port Road, Adelaide5000, Australia E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Current evidence suggests there is no difference between endoscopic laser surgery and radiotherapy with regards to oncological outcomes of early laryngeal cancer. Patient management may therefore be directed towards voice and quality of life outcomes. This systematic review compares functional outcomes with respect to voice character, swallowing outcomes and quality of life for endoscopic laser surgery versus radiotherapy for T1 and T2 stage laryngeal carcinoma.

Method

Search terminology was designed by both authors and used in Cochrane, PubMed and Web of Science databases. Studies of adult patients treated for primary T1 and T2 laryngeal squamous cell carcinoma utilising one objective (validated) measure of quality of life, swallowing or voice were included.

Results

Initial searches identified 1767 studies. After inclusion and exclusion criteria were applied, 42 studies were identified for full-text review.

Conclusion

This review concluded that neither treatment is clearly advantageous. Future research should be composed of further prospective studies that use a standardised assessment regime to allow valid comparison.

Keywords

Laryngeal NeoplasmsLaser TherapyRadiotherapyLasersQuality Of Life
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 10 , October 2022 , pp. 898 - 908
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr K Boyle takes responsibility for the integrity of the content of the paper

References

World Health Organisation. Global cancer observatory. In: https://gco.iarc.fr/today/home [3 April 2021]Google Scholar
Yoo, J, Lacchetti, C, Hammond, JA, Gilbert, RW. Role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: a systematic review. Head Neck 2014;36:1807–19CrossRefGoogle ScholarPubMed
Warner, L, Chudasama, J, Kelly, CG, Loughran, S, McKenzie, K, Wright, R et al. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database of Systematic Reviews 2014;(12):CD002027Google ScholarPubMed
Guimarães, AV, Dedivitis, RA, Matos, LL, Aires, FT, Cernea, CR. Comparison between transoral laser surgery and radiotherapy in the treatment of early glottic cancer: a systematic review and meta-analysis. Sci Rep 2018;8:11900CrossRefGoogle ScholarPubMed
Greulich, MT, Parker, NP, Lee, P, Merati, AL, Misono, S. Voice outcomes following radiation versus laser microsurgery for T1 glottic carcinoma: systematic review and meta-analysis. Otolaryngol Head Neck Surg 2015;152:811–19CrossRefGoogle ScholarPubMed
Du, G, Liu, C, Yu, W, Li, J, Li, W, Wang, C et al. Voice outcomes after laser surgery vs. radiotherapy of early glottic carcinoma: a meta-analysis. Int J Clin Exp Med 2015;8:17206–13Google ScholarPubMed
Howick, J, Chalmers, I, Lind, J, Glasziou, P, Greenhalgh, T, Heneghan, C et al. Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. In: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence [3 April 2021]Google Scholar
Liberati, A, Altman, DG, Tetzlaff, J, Mulrow, C, Gøtzsche, PC, Ioannidis, JPA et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:2700CrossRefGoogle ScholarPubMed
Aaltonen, LM, Rautiainen, N, Sellman, J, Saarilahti, K, Mäkitie, A, Rihkanen, H et al. Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy. Int J Radiation Oncol Biol Phys 2014;90:255–60CrossRefGoogle ScholarPubMed
Karnell, MP, Melton, SD, Childes, JM, Coleman, TC, Dailey, SA, Hoffman, HT. Reliability of clinician-based (GRBAS and CAPE-V) and patient-based (V-RQOL and IPVI) documentation of voice disorders. J Voice 2007;21:576–90CrossRefGoogle ScholarPubMed
Elner, A, Fex, S. Carbon dioxide laser as primary treatment of glottic t1s and t1a tumours. Acta Otolaryngol 1988;105:135–9CrossRefGoogle Scholar
van Gogh, CDL, Verdonck-De Leeuw, IM, Wedler-Peeters, J, Langendijk, JA, Mahieu, HF. Prospective evaluation of voice outcome during the first two years in male patients treated by radiotherapy or laser surgery for T1a glottic carcinoma. Eur Arch Otorhinolaryngol 2012;269:1647–52Google ScholarPubMed
Jotic, A, Stankovic, P, Jesic, S, Milovanovic, J, Stojanovic, M, Djukic, V. Voice quality after treatment of early glottic carcinoma. J Voice 2012;26:381–9CrossRefGoogle ScholarPubMed
Bahannan, AA, Zábrodsky, M, Cerny, L, Cbovanec, M, Lobynska, R. Quality of life following endoscopic resection or radiotherapy for early glottic cancer. Saudi Med J 2007;28:598–602Google ScholarPubMed
Kucuk, H, Kurnaz, SC, Kutlar, G. Treatment expectations and quality of life outcomes of patients with laryngeal cancer based on different treatment methods. Eur Arch Otorhinolaryngol 2015;272:1245–50CrossRefGoogle ScholarPubMed
Stoeckli, SJ, Guidicelli, M, Schneider, A, Huber, A, Schmid, S. Quality of life after treatment for early laryngeal carcinoma. Eur Arch Otorhinolaryngol 2001;258:96–9CrossRefGoogle ScholarPubMed
Laoufi, S, Mirghani, H, Janot, F, Hartl, DM. Voice quality after treatment of T1a glottic cancer. Laryngoscope 2014;124:1398–1401Google ScholarPubMed
Smith, JC, Johnson, JT, Cognetti, DM, Landsittel, DP, Gooding, WE, Cano, ER et al. Quality of life, functional outcome, and costs of early glottic cancer. Laryngoscope 2003;113:68–76CrossRefGoogle ScholarPubMed
Loughran, S, Calder, N, MacGregor, FB, Carding, P, MacKenzie, K. Quality of life and voice following endoscopic resection or radiotherapy for early glottic cancer. Clin Otolaryngol 2005;30:42–7CrossRefGoogle ScholarPubMed
Kujath, M, Kerr, P, Myers, C, Bammeke, F, Lambert, P, Cooke, A et al. Functional outcomes and laryngectomy-free survival after transoral CO 2 laser microsurgery for stage 1 and 2 glottic carcinoma. J Otolaryngol Head Neck Surg 2011;40:49–58Google ScholarPubMed
Luo, CM, Fang, TJ, Lin, CY, Chang, JTC, Liao, CT, Chen, IH et al. Transoral laser microsurgery elevates fundamental frequency in early glottic cancer. J Voice 2012;26:596–601CrossRefGoogle ScholarPubMed
Robertson, SM, Yeo, JCL, Sabey, L, Young, D, MacKenzie, K. Effects of tumor staging and treatment modality on functional outcome and quality of life after treatment for laryngeal cancer. Head Neck 2013;35:1759–63CrossRefGoogle ScholarPubMed
Ozturk, K, Turhal, G, Durusuy, D, Sahin, E, Akagunduz, O, Eyigor, S et al. Long-term swallowing outcomes of radiotherapy and transoral laser microsurgery for T1 glottic cancer treatment. Clin Otolaryngol 2021;46:340–6CrossRefGoogle ScholarPubMed
Smith, RAJ, Lockey, MW, Smith, RA Jr, Lockey, MW. Carcinoma in situ and T-1 squamous cell carcinoma of the glottis: the Mississippi Baptist Medical Center experience. J Miss State Med Assoc 1989;30:365–70Google ScholarPubMed
Bradley, PJ, MacKenzie, K, Wight, R, Pracy, P, Paleri, V. Consensus statement on management in the UK: transoral laser assisted microsurgical resection of early glottic cancer. Clin Otolaryngol 2009;34:367–73CrossRefGoogle ScholarPubMed
Lydiatt, WM, Patel, SG, O'Sullivan, B, Brandwein, M, Ridge, J, Migliacci, J et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67:122–37CrossRefGoogle ScholarPubMed
Brandenburg, JH. Laser cordotomy versus radiotherapy: an objective cost analysis. Ann Otol Rhinol Laryngol 2001;110:312–18CrossRefGoogle ScholarPubMed
Czecior, E, Orecka, B, Pawlas, P, Mrówka-Kata, K, Namysłowski, G, Składowski, K et al. Comparative assessment of the voice in patients treated for early glottis cancer by laser cordectomy or radiotherapy. Otolaryngol Polska 2012;66:407–12CrossRefGoogle ScholarPubMed
Demir, B, Binnetoglu, A, Gurol, E, Oysu, C. Comparison of voice quality of life in early stage glottic carcinoma treated with endoscopic cordectomy using radiofrequency microdissection electrodes, laser cordectomy and radiotherapy. J Voice 2021;35:477–82Google ScholarPubMed
Gandhi, S, Gupta, S, Rajopadhye, G. A comparison of phonatory outcome between trans-oral CO(2) Laser cordectomy and radiotherapy in T1 glottic cancer. Eur Arch Otorhinolaryngol 2018;275:2783–6CrossRefGoogle Scholar
Hong, YT, Park, MJ, Hong, HK. Characteristics of speech production in patients with T1 glottic cancer who underwent laser cordectomy or radiotherapy. Logoped Phoniatr Vocol 2018;43:120–8CrossRefGoogle ScholarPubMed
Kono, T, Saito, K, Yabe, H, Uno, K, Ogawa, K. Comparative multidimensional assessment of laryngeal function and quality of life after radiotherapy and laser surgery for early glottic cancer. Head Neck 2016;38:1085–90Google ScholarPubMed
Krengli, M, Policarpo, M, Manfredda, I, Aluffi, P, Gambaro, G, Panella, M et al. Voice quality after treatment for T1a glottic carcinoma: radiotherapy versus laser cordectomy. Acta Oncologica 2004;43:284–9CrossRefGoogle ScholarPubMed
Lombardo, N, Aragona, T, Alsayyad, S, Pelaia, G, Terracciano, R, Savino, R. Objective and self-evaluation voice analysis after transoral laser cordectomy and radiotherapy in T1a-T1b glottic cancer. Lasers Med Sci 2018;33:141–7CrossRefGoogle ScholarPubMed
Ma, Y, Green, R, Pan, S, McCabe, D, Goldberg, L, Woo, P. Long-term voice outcome following radiation versus laser microsurgery in early glottic cancer. J Voice 2019;33:176–82CrossRefGoogle ScholarPubMed
Mcguirt, WF, Blalock, D, Koufman, JA, Feehs, RS, Hilliard, AJ, Greven, K et al. Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch Otolaryngol Head Neck Surg 1994;120:951–5CrossRefGoogle ScholarPubMed
Milovanovic, J, Djukic, V, Milovanovic, A, Trivic, AS, Baljosevic, AS, Vukasinovic, MM. Clinical outcome of early glottic carcinoma in Serbia. Auris Nasus Larynx 2013;40:394–9CrossRefGoogle ScholarPubMed
Núñez Batalla, F, Caminero Cueva, MJ, Señaris González, B, Llorente Pendás, JL, Gorriz Gil, C, López Llames, A et al. Voice quality after endoscopic laser surgery and radiotherapy for early glottic cancer: objective measurements emphasizing the voice handicap index. Eur Arch Otorhinolaryngol 2008;265:543–8CrossRefGoogle ScholarPubMed
Policarpo, M, Aluffi, P, Brovelli, F, Borello, G, Pia, F. Oncological and functional results of CO2 laser cordectomy. Acta Otorhinolaryngol Ital 2004;24:267–74Google ScholarPubMed
Rydell, R, Schalén, L, Fex, S, Elner, Å. Voice evaluation before and after laser excision vs. radiotherapy of t1a glottic carcinoma. Acta Otolaryngol 1995;115:560–5CrossRefGoogle ScholarPubMed
Sjögren, E, van Rossum, MA, Langeveld, TPM, Voerman, M, Van De Kamp, V, Friebel, M et al. Voice outcome in Tla midcord glottic carcinoma. Arch Otolaryngol Head Neck Surg 2008;134:965–72CrossRefGoogle Scholar
Surmeli, M, Oysu, C, Yilmaz, AAŞ, Deveci, I, Karabulut, B, Sunter, AV et al. Comparison of voice quality and cost effectiveness of endoscopic cordectomy using microdissection electrodes with laser cordectomy and radiotherapy. Turk Arch Otorhinolaryngol 2019;57:1–6Google ScholarPubMed
Tamura, E, Kitahara, S, Ogura, M, Kohno, N. Voice quality after laser surgery or radiotherapy for T1a glottic carcinoma. Laryngoscope 2003;113:910–14CrossRefGoogle ScholarPubMed
Goor, KM, Peeters, AJGE, Mahieu, HF, Loughran, S, Mckenzie, K, Wight, R et al. Cordectomy by CO2 laser or radiotherapy for small T1a glottic carcinomas: costs, local control, survival, quality of life, and voice quality. Head Neck 2007;29:128–36Google ScholarPubMed
Peeters, AJGE, van Gogh, CDL, Goor, KM, Verdonck-de Leeuw, IM, Langendijk, JA, Mahieu, HF. Health status and voice outcome after treatment for T1a glottic carcinoma. Eur Arch Otorhinolaryngol 2004;261:534–40CrossRefGoogle ScholarPubMed
Cerezo, L, Lopez, M, Martin, M, Garcia, J, Ibafiez, Y, Hinojar, A. Voice quality in patients treated with surgery or radiotherapy for early glottic cancer – a comparative study. Eur J Cancer 2011;47:553–4CrossRefGoogle Scholar
Dinapoli, N, Parrilla, C, Galli, J, Autorino, R, Miccichè, F, Bussu, F et al. Multidisciplinary approach in the treatment of T1 glottic cancer: the role of patient preference in a homogenous patient population. Strahlenther Onkol 2010;186:607–13CrossRefGoogle Scholar
Kerr, P, Taylor, SM, Rigby, M, Myers, C, Osborn, H, Lambert, P et al. Oncologic and voice outcomes after treatment of early glottic cancer: transoral laser microsurgery versus radiotherapy. J Otolaryngol Head Neck Surg 2012;41:381–8Google ScholarPubMed
Oridate, N, Homma, A, Suzuki, S, Nakamaru, Y, Suzuki, F, Hatakeyama, H et al. Voice-related quality of life after treatment of laryngeal cancer. Arch Otolaryngol Head Neck Surg 2009;135:363–8Google ScholarPubMed
Osborn, HA, Hu, A, Venkatesan, V, Nichols, A, Franklin, J, Yoo, J et al. Comparison of endoscopic laser resection versus radiation therapy for the treatment of early glottic carcinoma. J Otolaryngol Head Neck Surg 2011;40:200–4Google ScholarPubMed
Remmelts, AJ, Hoebers, FJP, Klop, WMC, Balm, AJM, Hamming-Vrieze, O, van den Brekel, MWM. Evaluation of lasersurgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice. Eur Arch Otorhinolaryngol 2013;270:2079–87Google ScholarPubMed
Shen, J, Hay, K, Ma, J, Zhen, H, Guan, H, Wang, W et al. Clinical analysis of EBRT vs TLM in the treatment of early (T1-T2N0) glottic laryngeal cancer. J Cancer 2020;11:6686–94CrossRefGoogle ScholarPubMed
Taylor, SM, Kerr, P, Fung, K, Aneeshkumar, MK, Wilke, D, Jiang, Y et al. Treatment of T1b glottic SCC: laser vs. radiation Canadian multicenter study. J Otolaryngol Head Neck Surg 2013;42:22CrossRefGoogle ScholarPubMed
Supplementary material: File

Boyle and Jones et al. supplementary material

Table S1

Download Boyle and Jones et al. supplementary material(File)
File 300.7 KB