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Familial cholesteatoma in East Anglia, UK

Published online by Cambridge University Press:  20 May 2008

P Prinsley
P Prinsley*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, James Paget and Norfolk and Norwich University Hospitals, UK
*
Address for correspondence: Mr P Prinsley, 26 Eaton Rd, Norwich NR4 6PZ, UK. E-mail: [email protected]
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Abstract

Objective:

To report a cluster of families affected by cholesteatoma in the East Anglia region of the UK.

Setting:

Otology service for the population of Norfolk and North Suffolk, East Anglia, UK.

Method:

Prospective and systematic collection of family history data for patients presenting with cholesteatoma over 10 years.

Result:

Several families were identified with affected individuals over several generations.

Conclusion:

There is likely to be a genetic propensity for cholesteatoma in some individuals.

Keywords

CholesteatomaGenetic DiseasesAetiology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 3 , March 2009 , pp. 294 - 297
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Lesinkas, E, Kasinskas, R, Vainutiene, V. Middle ear cholesteatoma; present day concepts of eitiology and pathogenesis. Medicina (Kaunus) 2002;38:1066–71Google Scholar
2 Tos, M. A new pathogenesis for mesotympanic (congenital) cholesteatoma. Laryngoscope 2000;110:1890–7Google Scholar
3 Podoshin, L, Fradis, M, Ben David, Y, Margalit, A, Tamir, A, Epstein, L. Cholesteatoma; an epidemiologic study among members of kibbutzim in Northern Israel. Ann Otol Rhinol Laryngol 1986;95:365–8CrossRefGoogle ScholarPubMed
4 Homoe, P, Rosborg, J. Family cluster of cholesteatoma. J Laryngol Otol 2007;121:65–7Google Scholar
5 Albino, AP, Reed, JA, Bogdany, JK, Sassoon, J, Desloge, RB, Parisier, SC. Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications. Am J Otol 1998;9:266–72Google Scholar
6 Tokuriki, M, Noda, I, Saito, T, Narita, N, Sunaga, H, Tsuzuki, H et al. Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays. Laryngoscope 2003;113:808–14Google Scholar
7 Kwon, KH, Kim, SJ, Kim, HJ, Jung, HH. Analysis of gene expression profiles in cholesteatoma using oligonucleotide microarray. Acta Otol 2006;126:691–7Google Scholar