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Expression of a disintegrin and metalloproteinase-33 protein in vocal fold polyps

Published online by Cambridge University Press:  08 July 2015

M V Akdogan ,
H Erinanc ,
O Topal  and
S S Erbek
M V Akdogan*
Affiliation:
Department of Otolaryngology, Baskent University Faculty of Medicine, Ankara, Turkey
H Erinanc
Affiliation:
Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkey
O Topal
Affiliation:
Department of Otolaryngology, Baskent University Faculty of Medicine, Ankara, Turkey
S S Erbek
Affiliation:
Department of Otolaryngology, Baskent University Faculty of Medicine, Ankara, Turkey
*
Address for correspondence: Dr M V Akdogan, Department of Otorhinolaryngology, Baskent University Konya Research and Teaching Center, Saray Caddesi No. 1 Selcuklu, Konya 42080, Turkey Fax: +90 332 2570637 E-mail: [email protected]
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Abstract

Background:

This study aimed to evaluate the association of a disintegrin and metalloproteinase-33 protein (‘ADAM-33’) expression in vocal polyp formation and to determine its correlation with clinical characteristics.

Methods:

Medical charts and histological sections of 32 patients diagnosed with vocal polyps who underwent surgery were analysed. Controls were histopathologically normal vocal fold tissues obtained from 36 patients who underwent surgery for laryngeal squamous cell carcinoma. Immunohistochemical staining was performed to detect ADAM-33 expression in epithelial cells, stroma and vessels.

Results:

All epithelial, stromal and vascular staining scores were significantly greater in polyp tissue than in controls (p < 0.001). Stromal ADAM-33 staining scores were higher in vocal polyp patients with a symptom duration of less than six months (p < 0.05). Vocal overuse or the presence of reflux symptoms, sinonasal symptoms or allergy did not affect ADAM-33 immunostaining scores (p = 0.05).

Conclusion:

In this study, ADAM-33 immunostaining was significantly increased in vocal polyps. Therefore, over-expression of this protein may be associated with vocal polyp pathogenesis.

Keywords

A Disintegrin and Metalloproteinase Domain 33 ProteinHumanVocal CordsLaryngeal DiseasesImmunohistochemistryAirway RemodelingAngiogenesis Inducing Agents
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 7 , July 2015 , pp. 688 - 692
Copyright
Copyright © JLO (1984) Limited 2015 

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