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Experimental study on the aetiology of benign paroxysmal positional vertigo due to canalolithiasis: comparison between normal and vestibular dysfunction models

Published online by Cambridge University Press:  14 January 2014

K Otsuka ,
M Negishi ,
M Suzuki ,
T Inagaki ,
M Yatomi ,
U Konomi ,
T Kondo  and
Y Ogawa
K Otsuka*
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
M Negishi
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
M Suzuki
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
T Inagaki
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
M Yatomi
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
U Konomi
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
T Kondo
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
Y Ogawa
Affiliation:
Department of Otolaryngology, Tokyo Medical University, Japan
*
Address for correspondence: Dr K Otsuka, Department of Otolaryngology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan Fax: +81 3 3346 9275 E-mail: [email protected]
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Abstract

Objectives:

Using American bullfrog models under normal conditions and under vestibular dysfunction, we investigated whether mechanical vibration applied to the ear could induce otoconial dislodgement.

Methods:

Vibration was applied to the labyrinth of the bullfrog using a surgical drill. The time required for the otoconia to dislodge from the utricular macula was measured. Vestibular dysfunction models were created and the dislodgement time was compared with the normal models. The morphology of the utricular macula was also investigated.

Results:

In the normal models, the average time for otoconial dislodgement to occur was 7 min and 36 s; in the vestibular dysfunction models, it was 2 min and 11 s. Pathological investigation revealed that the sensory hairs of the utricle were reduced in number and that the sensory cells became atrophic in the vestibular dysfunction models.

Conclusion:

The otoconia of the utricle were dislodged into the semicircular canal after applying vibration. The time to dislodgement was significantly shorter in the vestibular dysfunction models than in the normal models; the utricular macula sustained significant morphological damage.

Keywords

Vertigo, Benign Paroxysmal PositionalBPPVVibrationOtoconiaUtricleTraumaOtologic Surgical ProcedureBullfrogIn Vitro
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 1 , January 2014 , pp. 68 - 72
Copyright
Copyright © JLO (1984) Limited 2014 

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