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Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy

Published online by Cambridge University Press:  29 June 2007

Walter Habermann ,
Andreas Eherer ,
Franz Lindbichler ,
Johann Raith  and
Gerhard Friedrich
Walter Habermann*
Affiliation:
Department of ENT, University of Graz, Medical School, Austria.
Andreas Eherer
Affiliation:
Department of Internal MedicineUniversity of Graz, Medical School, Austria.
Franz Lindbichler
Affiliation:
Department of Radiology, University of Graz, Medical School, Austria.
Johann Raith
Affiliation:
Department of Radiology, University of Graz, Medical School, Austria.
Gerhard Friedrich
Affiliation:
Department of ENT, University of Graz, Medical School, Austria.
*
Address for correspondence: W. Habermann, Department of ENT, University of Graz, Medical School, Auenbruggerplatz 20, A-8010 Graz, Austria e-mail: [email protected].
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Abstract

The aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastropharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a videolaryngo/stroboscopy were completed. The symptom questionnaire and the video-laryngo/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy.

Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (p<0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (p<0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients.

A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient.

Keywords

LaryngitisVoice disordersGastrooesophageal refluxProton pumpDrug therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 8 , August 1999 , pp. 734 - 739
Copyright
Copyright © JLO (1984) Limited 1999

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