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Endoscopic laser treatment in pre-malignant and malignant vocal fold epithelial lesions

Published online by Cambridge University Press:  08 March 2006

E. E. G. Remijn ,
H. A. M. Marres  and
F. J. A. van den Hoogen
E. E. G. Remijn
Affiliation:
Department of Otorhinolaryngology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
H. A. M. Marres
Affiliation:
Department of Otorhinolaryngology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
F. J. A. van den Hoogen
Affiliation:
Department of Otorhinolaryngology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
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Abstract

Endoscopic laser treatment was performed in 43 patients with pre-malignant or malignant vocal fold epithelial lesions, 10 were treated with endoscopic laser surgery for dysplasia, 12 for carcinoma in situ (CIS), five for verrucous carcinoma and 16 patients for squamous cell carcinoma (SCC). Thirty-two patients received laser therapy as their first therapy, whereas 11 patients had had previous radiation therapy for laryngeal carcinoma (n = 9) or CIS (n = 2).

Recurrence after initial laser therapy necessitating re-treatment (a second laser treatment or radiotherapy) occurred in nine out of 32 patients (28 per cent), thus 23 (72 per cent) were maintained free of disease during the follow-up period.

Besides the 32 patients without previous therapy, patients who had already undergone radiat on therapy were also included in this study. In this group there were nine patients with SCC, one patient with CIS and one with dysplasia. They all underwent laser therapy. Four were free ofdisease during follow-up (36 per cent) and seven developed recurrences. Six (58 per cent of allpatients with previous radiation therapy) underwent total laryngectomy.

Keywords

Laser SurgeryCarcinoma in SituCarcinomaVocal Cords
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 116 , Issue 12 , December 2002 , pp. 1019 - 1024
Copyright
© Royal Society of Medicine Press Limited 2002

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