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Endolymphatic hydrops and Ménière's disease: a lesion meta-analysis

Published online by Cambridge University Press:  19 September 2014

D J Pender
D J Pender*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Columbia University Medical Center, New York, New York, USA
*
Address for correspondence: Dr Daniel J Pender, 145 West 86th Street Suite 1C, New York City, New York 10024, USA Fax: +1-212-249-0474 E-mail: [email protected]
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Abstract

Objective:

To determine whether the distribution of membrane lesions associated with Ménière's disease is random, as might be expected from a pervasive process such as hydrops, or orderly, as might be expected if membrane resistance is graded.

Method:

A meta-analysis of temporal bone reports on 184 specimens demonstrating endolymphatic hydrops was undertaken to determine membrane lesion evolution and distribution.

Results:

Lesion distribution was found to be orderly and cochleocentric. No random scattershot lesions were reported in any study. Disease always started in the cochlear apex, even in non-symptomatic cases, and then involved the saccule, utricle, ampullae and canal system in that precise sequence as the disease progressed.

Conclusion:

The orderly lesion progression in the otopathology associated with Ménière's disease suggests that the hydropic process has a graded non-random effect on the labyrinth. These findings suggest a pathological staging system that may be useful in temporal bone evaluation.

Keywords

Meniere's DiseaseLabyrinthEndolymphatic HydropsHistopathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 10 , October 2014 , pp. 859 - 865
Copyright
Copyright © JLO (1984) Limited 2014 

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Footnotes

Presented at the International Otopathology Society Meeting held at Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, 10–11 June 2013

References

1Ménière, P. Report on lesions of the inner ear causing symptoms of apolectiform cerebral congestion [in French]. Gazzette Medicale de Paris 1861;16:597–601Google Scholar
2Duplay, S. Some diseases of the inner ear [in French]. Arch Gen Med 1872:711–22Google Scholar
3Hallpike, CS, Cairns, H. Observations on the pathology of Ménière's syndrome. J Laryngol Otol 1938;53:625–55Google Scholar
4Witmaack, K. In: Henke, F, Lubarsch, O eds. Handbook of Special Pathological Anatomy and Histology [in German]. 1926;12:290Google Scholar
5Lindsay, JR. Labyrinthine dropsy and Ménière's disease. Arch Otolaryngol 1942;35:853–67CrossRefGoogle Scholar
6Williams, HL. The syndrome of physical or intrinsic allergy of the head. Proc Staff Meet Mayo Clin 1946;21:58–64Google ScholarPubMed
7Schuknecht, HA, Benitez, JT, Beekhuis, J. Further observations on the pathology of Ménière's disease. Ann Otol Rhinol Laryngol 1962;71:1039–53Google Scholar
8Schuknecht, HF, Gulya, AJ. Endolymphatic hydrops. An overview and classification. Ann Otol Rhinol Laryngol Suppl 1983;106:1–20Google Scholar
9Antoli-Candela, F. The histopathology of Ménière's disease. Acta Otolaryngol 1976;340:1–42Google Scholar
10Yamashita, T, Schuknecht, HF. Apical endolymphatic hydrops. Arch Otolaryngol 1982;108:463–6CrossRefGoogle ScholarPubMed
11Altmann, F, Kornfeld, M. Histological studies of Ménière's disease. Ann Otol Rhinol Laryngol 1965;74:915–43CrossRefGoogle ScholarPubMed
12Merchant, SN, Adams, JC, Nadol, JB Jr.Pathophysiology of Ménière's syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol 2005;26:74–81Google Scholar
13Fraysse, BG, Alonso, A, House, WF. Ménière's disease and endolymphatic hydrops: clinical-histopathological correlations. Ann Otol Rhinol Laryngol 1980;89:2–22Google Scholar
14Sperling, NM, Paparella, MM, Yoon, TH, Zelterman, D. Symptomatic versus asymptomatic endolymphatic hydrops: a histological comparison. Laryngoscope 1993;103:277–85CrossRefGoogle Scholar
15Perlman, HB. The saccule: Observations on a differentiated re-enforced area of the saccular wall in man. Arch Otolaryngol 1940;32:678–91Google Scholar
16Machiavelli, N. The Prince [in Italian]. Florence: Antonio Blado d'Asola, 1532Google Scholar
17Nakashima, T, Naganawa, S, Pyykko, I. Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol 2009;129:5–8Google Scholar
18Antonelli, PJ, Parell, GJ, Becker, GD, Paparella, MM. Temporal bone pathology in scuba diving deaths. Otolaryngol Head Neck Surg 1993;109:514–21Google Scholar
19Kimura, RS. Distribution, structure and function of the dark cells of the vestibular labyrinth. Ann Otol Rhinol Laryngol 1969;78:542–61CrossRefGoogle ScholarPubMed
20Eckhard, A, Gleiser, C, Arnold, H, Rask-Andersen, H, Kumagami, H, Muller, H et al. Water channel proteins in the inner ear and their link to hearing impairment and deafness. Mol Aspects Med 2012;33:612–37Google Scholar
21Guild, SR. The circulation of the endolymph. Am J Anat 1927;39:57–81Google Scholar
22Becvarovski, Z, Zappia, JJ. The ZB mastoid oscillation protocol (ZBMOP) in Ménière's disease and ductolithiasis. Otolaryngol Head Neck Surg 2002;127:491–2CrossRefGoogle ScholarPubMed