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Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study

Published online by Cambridge University Press:  05 December 2016

A R Singh ,
A Rai ,
M Aftab ,
S Jain  and
M Singh
A R Singh*
Affiliation:
Department of ENT, Head & Neck Surgery, Moti Lal Nehru Medical College, Allahabad, India
A Rai
Affiliation:
Department of ENT, Head & Neck Surgery, Moti Lal Nehru Medical College, Allahabad, India
M Aftab
Affiliation:
Department of ENT, Head & Neck Surgery, Moti Lal Nehru Medical College, Allahabad, India
S Jain
Affiliation:
Department of ENT, Head & Neck Surgery, Moti Lal Nehru Medical College, Allahabad, India
M Singh
Affiliation:
Department of ENT, Head & Neck Surgery, Moti Lal Nehru Medical College, Allahabad, India
*
Address for correspondence: Dr A R Singh, Department of ENT, Head & Neck Surgery, Moti Lal Nehru Medical College, Allahabad UP-211001, India E-mail: [email protected]
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Abstract

Objective:

This study compared the therapeutic efficacy of steroidal and non-steroidal agents for treating oral lichen planus.

Methods:

Forty patients with clinical and/or histologically proven oral lichen planus were randomly placed into four groups and treated with topical triamcinolone, oral dapsone, topical tacrolimus or topical retinoid for three months. Pre- and post-treatment symptoms and signs were scored for each patient.

Results:

Patients in all treatment groups showed significant clinical improvement after three months (p < 0.05), with steroidal and non-steroidal agents having equal efficacy. Furthermore, of the non-steroidal drugs, oral dapsone had greater efficacy than topical retinoid (p < 0.05). However, no significant differences in outcome were recorded for oral dapsone vs topical tacrolimus (p > 0.05) and for topical retinoid vs topical tacrolimus (p > 0.05).

Conclusion:

Non-steroidal drugs such as dapsone, tacrolimus and retinoid are as efficacious as steroidal drugs for treating oral lichen planus, and avoid the side effects associated with steroids.

Keywords

DapsoneLichen PlanusOralRetinoidsTacrolimusTriamcinolone
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 1 , January 2017 , pp. 69 - 76
Copyright
Copyright © JLO (1984) Limited 2016 

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