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Effects of agmatine sulphate on facial nerve injuries

Published online by Cambridge University Press:  26 January 2017

O Surmelioglu ,
L Sencar ,
S Ozdemir ,
O Tarkan ,
M Dagkiran ,
N Surmelioglu ,
U Tuncer  and
S Polat
O Surmelioglu*
Affiliation:
Department of Otorhinolaryngology, Cukurova University, Adana, Turkey
L Sencar
Affiliation:
Department of Histology, Faculty of Medicine, Cukurova University, Adana, Turkey
S Ozdemir
Affiliation:
Department of Otorhinolaryngology, Cukurova University, Adana, Turkey
O Tarkan
Affiliation:
Department of Otorhinolaryngology, Cukurova University, Adana, Turkey
M Dagkiran
Affiliation:
Department of Otorhinolaryngology, Cukurova University, Adana, Turkey
N Surmelioglu
Affiliation:
Department of Clinical Pharmacy, Faculty of Pharmacy, Cukurova University, Adana, Turkey
U Tuncer
Affiliation:
Department of Otorhinolaryngology, Cukurova University, Adana, Turkey
S Polat
Affiliation:
Department of Histology, Faculty of Medicine, Cukurova University, Adana, Turkey
*
Address for correspondence: Dr Ozgur Surmelioglu, Department of Otorhinolaryngology, Faculty of Medicine, Cukurova University, Adana, Turkey Fax: +90 322 338 6527 E-mail: [email protected]
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Abstract

Objective:

To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.

Methods:

The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.

Results:

Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).

Conclusion:

Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.

Keywords

Facial NerveAgmatineNerve Regeneration
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 3 , March 2017 , pp. 221 - 226
Copyright
Copyright © JLO (1984) Limited 2017 

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