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Effectiveness of corticosteroids in otitis media with effusion: an experimental study

Published online by Cambridge University Press:  20 April 2007

H Yaman ,
K Ozturk ,
Y Uyar  and
M Gurbilek
H Yaman*
Affiliation:
Department of Otolaryngology, Meram Medical Faculty, Selcuk University, Konya, Turkey
K Ozturk
Affiliation:
Department of Otolaryngology, Meram Medical Faculty, Selcuk University, Konya, Turkey
Y Uyar
Affiliation:
Department of Otolaryngology, Meram Medical Faculty, Selcuk University, Konya, Turkey
M Gurbilek
Affiliation:
Department of Biochemistry, Meram Medical Faculty, Selcuk University, Konya, Turkey
*
Address for correspondence: Dr Huseyin Yaman, Selcuk Universitesi, Meram Tip Fakultesi, Kulak Burun Bogaz Hastaliklari Anabilim Dali, 42080 Meram, Konya, Turkey. Fax: +90 332 2236181 E-mail: [email protected]
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Abstract

Objective:

The aim of the present study was to investigate the dose-related effectiveness of corticosteroids in the management of otitis media with effusion, by using the objective assessment techniques of tympanometry and cytokine measurement.

Materials and methods:

The eustachian tubes of 42 male rats were obstructed. Thirty-six subjects with effusion were randomly divided into three equal groups: controls; 0.5 mg/kg/day corticosteroid; and 1 mg/kg/day corticosteroid. Concentrations of interleukin-1β and tumour necrosis factor α in the middle-ear effusions were analysed using enzyme-linked immunosorbent assay.

Results:

An effusion occurred on the 14th post-operative day and was present on the 30th post-operative day in the control group. Otomicroscopic examination and tympanometric measurement showed an improvement in the intervention groups. There was a significant difference between both intervention groups and the control group for both interleukin-1β and tumour necrosis factor α concentrations (p < 0.01). However, there was no significant difference between the 0.5 mg/kg and the 1 mg/kg corticosteroid groups (p > 0.05).

Conclusion:

The study confirmed a short term beneficial effect of systemic steroids on resolution of otitis media with effusion in a rat model. Our results support the theory that corticosteroids significantly decrease concentrations of both interleukin-1β and tumour necrosis factor α. In our model, the 0.5 mg/kg corticosteroid dose was as effective as the 1 mg/kg corticosteroid dose. Further studies should be carried out to determine the optimal dose and duration of corticosteroids in the treatment of otitis media with effusion.

Keywords

Otitis Media with EffusionAcoustic Impedence TestsTumour Necrosis Factor-αInterleukinesCorticosteroids
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 1 , January 2008 , pp. 25 - 30
Copyright
Copyright © JLO (1984) Limited 2007

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Footnotes

Presented at the XXVIIIth Congress of the Turkish National Otolaryngology and Head and Neck Surgery, 21–26 May 2005, Antalya, Turkey.

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