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The effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinate

Published online by Cambridge University Press:  12 October 2015

S Sengul ,
İ Kaygusuz ,
M M Akin ,
Ş Yalcin ,
T Karlidag ,
E Keles  and
İ Arslan
S Sengul
Affiliation:
Department of Otorhinolaryngology, Government Hospital, Karabük, Turkey
İ Kaygusuz*
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
M M Akin
Affiliation:
Department of Pathology, Medical Faculty, Firat University, Elazig, Turkey
Ş Yalcin
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
T Karlidag
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
E Keles
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
İ Arslan
Affiliation:
Department of Otorhinolaryngology, Government Hospital, Bingöl, Turkey
*
Address for correspondence: Prof. İ Kaygusuz, Department of Otorhinolaryngology, Firat UniversityMedical Faculty, 23200 Elazig, Turkey Fax: +90 424 238 80 96 E-mail: [email protected]
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Abstract

Objective:

This study aimed to assess the histopathological effect of OK-432 (Picibanil) on rabbit nasal turbinates.

Methods:

A total of 21 rabbits were divided into 3 treatment groups and various parts of both nasal turbinates were injected with 0.5 ml OK-432, 0.2 ml OK-432 or 0.6 ml saline (control). Bilateral nasal turbinates were later excised and studied under light microscopy to assess any histopathological changes.

Results:

Animals in the 0.2 ml and 0.5 ml OK-432 groups exhibited mild ciliary loss, goblet cell loss and epithelial damage, and a marked increase in inflammatory cell infiltration, submucosal vascularisation and fibrosis. There was a significant difference in histopathological changes between the two OK-432 treated groups. In addition, each OK-432 treated group had significantly more inflammatory cell infiltration, increased submucosal vascularisation and fibrosis compared with controls.

Conclusion:

The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size.

Keywords

TurbinatesHypertrophyNasal ObstructionPicibanil
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 12 , December 2015 , pp. 1208 - 1212
Copyright
Copyright © JLO (1984) Limited 2015 

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Footnotes

Presented as an oral poster at the 36th Turkish National Otorhinolaryngology Head and Neck Surgery Congress, 5–9 November, 2014. Antalya, Turkey

References

1Passali, D, Laureiello, M, Bellussi, L, Anselmi, M. Treatment of hypertrophy of the inferior turbinate: Long-term results in 382 patients randomly assigned to therapy. Ann Otol Rhinol Laryngol 1999;108:569–75CrossRefGoogle ScholarPubMed
2Myrthe, K, Hol, S, Huizing, EH. Treatment of inferior turbinate pathology. Rhinology 2000;38:157–76Google Scholar
3Lippert, BM, Werner, JA. Long term results after laser turbinectomy. Lasers Surg Med 1998;22:126–343.0.CO;2-R>CrossRefGoogle ScholarPubMed
4Elwany, S, Harrison, R. Inferior turbinectomy: comparison of four techniques. J Laryngol Otol 1990;104:206–9CrossRefGoogle ScholarPubMed
5Ito, H, Baba, S, Suziki, M. Severe perennial allergic rhinitis treated with Nd: yag Laser. Acta Otolaryngol 1996;525:14–17Google ScholarPubMed
6Chang, CW, Ries, WR. Surgical treatment of the inferior turbinate: New techniques. Curr Opin Otolaryngol Head Neck Surg 2004;12:53–7CrossRefGoogle ScholarPubMed
7Hol, MKS, Huizing, EH. Treatment of inferior turbinate pathology: a review and critical evaluation of the different techniques. Rhinology 2000;38:157–66Google Scholar
8Ogita, S, Tsutu, T, Tokiwa, T. OK-432 therapy in 64 patients with lymphangioma. J Pediatr Surg 1994;29:784–5CrossRefGoogle ScholarPubMed
9Ogita, S, Tsuto, T, Deguchi, E, Tokiwa, K, Nagashima, M, Iwai, N. OK-432 treatment for unresectable lymphangiomas in children. J Pediatr Surg 1991;26:263–70CrossRefGoogle ScholarPubMed
10Herrera, MA, Di Segni, R, Kaye, KW. Embolization of the internal spermatic vein with mechanical devices for the treatment of varicocele. In: Castaneda-Zuniga, WR, Tadavarthy, SM, eds. Interventional Radiology. Baltimore: Williams and Wilkins, 1992;100–10Google Scholar
11Institute of Animal Resources. Guide for the Care and Use of Laboratory Animals, 8th edn.Washington DC: National Research Council Press, 2011Google Scholar
12Swift, AC, Siegler, J. Intraturbinate ethanolamine oleate as a method of treatment in chronic non specific rhinitis. J Laryngol Otol 1984;100:417–20CrossRefGoogle Scholar
13Lafayette, P. Treatment of hypertrophied inferior turbinate by using sclerosing solutions. Arch Otolaryngol 1935;22:96–8Google Scholar
14Miyoshi, H, Ohshiba, S, Matsumoto, A, Takada, K. Haptoglobin prevents renal dysfunction associated with intravariceal infusion of ethanolamine oleate. Am J Gastroenterol 1991;86:1638–41Google ScholarPubMed
15Woods, H. Sclerosing submucosal injection of turbinates. BMJ 1937;1:359CrossRefGoogle Scholar
16Brewis, C, Pracy, JP, Albert, DM. Treatment of lymphangiomas of the head and neck in children by intralesional injection of OK-432 (Picibanil). Clin Otolaryngol 2000;25:130–4CrossRefGoogle ScholarPubMed
17Claesson, G, Gordon, L, Kuylenstierna, R. A revolutionary Japanese method for treatment of lymphangioma [in Swedish]. Läkartidningen 1998;95:2074–7Google ScholarPubMed
18Greinwald, JH Jr, Burke, DK, Sato, Y, Poust, RI, Kimura, K, Bauman, NM et al. Treatment of lymphangiomas in children: an update of Picibanil (OK-432) sclerotherapy. Otolaryngol Head Neck Surg 1998;121:381–7CrossRefGoogle Scholar
19Luzatto, C, Midrio, P, Tchaprassian, Z, Guglielmi, M. Sclerosing treatment of lymphangiomas with OK-432. Arch Dis Child 2000;82:316–18CrossRefGoogle Scholar
20Reinhardt, MA, Nelson, SC, Sencer, SF, Bostrom, BC, Kuracheck, SC, Nesb, ME. Treatment of childhood lymphangiomas with interferon-alpha. J Pediatr Hematol Oncol 1997;19:232–6CrossRefGoogle ScholarPubMed
21Schmidt, B, Schimpl, G, Höllwarth, ME. OK-432 therapy of lymphangiomas in children. Eur J Pediatr 1996;155:649–52CrossRefGoogle ScholarPubMed
22Smith, RJH, Burke, DK, Sato, Y, Poust, RI, Kimura, K, Bauman, NM. OK-432 therapy for lymphangiomas. Arch Otolaryngol Head Neck Surg 1996;122:1195–9CrossRefGoogle ScholarPubMed
23Ogita, K, Suita, S, Taguchi, T, Yamanouchi, T, Masumoto, K, Tsukimori, K et al. Outcome of fetal cystic hygroma and experience of intrauterine treatment. Fetal Diagn Ther 2001;16:105–10CrossRefGoogle ScholarPubMed
24Hamamoto, S, Okuma, T, Yamamoto, A, Kageyama, K. Radiofrequency ablation and immunostimulant OK-432: combination therapy enhances systemic antitumor immunity for treatment of VX2 lung tumors in rabbits. Radiology 2013;267:405–13CrossRefGoogle ScholarPubMed
25Parekh, D, Stewart, M, Joseph, C, Lawson, HH. Plunging ranula: a report of 3 cases and a review of the literature. Br J Surg 1987;74:307–9CrossRefGoogle Scholar
26Yoshimura, Y, Obara, S, Kondoh, T. A comparison of three methods used for treatment of the ranula. J Oral Maxillofac Surg 1995;53:280–2CrossRefGoogle ScholarPubMed
27Woo, JS, Hwang, SJ, Lee, HM. Recurrent plunging ranula treated with OK-432. Eur Arch Otorhinolaryngol 2003;260:226–8CrossRefGoogle ScholarPubMed
28Kim, KH, Sung, MW, Roh, JL. Sclerotherapy for congenital lesions in the head and neck. Otolaryngol Head Neck Surg 2004;131:307–16CrossRefGoogle ScholarPubMed
29Chang, HS, Yoon, JH, Chung, WY, Park, CS. Sclerotherapy with OK-432 for recurrent cystic thyroid nodule. Yonsei Med J 1998;39:367–71CrossRefGoogle ScholarPubMed
30Coste, A, Yona, L, Blumen, M. Radiofrequency is a safe and effective treatment of turbinate hypertrophy. Laryngoscope 2001;111:894–9CrossRefGoogle ScholarPubMed
31Berger, G, Ophir, D, Pitaro, K, Landsberg, R. Histopathological changes after coblation inferior turbinate reduction. Arch Otolaryngol Head Neck Surg 2008;134:8–13CrossRefGoogle ScholarPubMed
32Kaplama, ME, Kaygusuz, İ, Akpolat, N, Karlıdağ, T, Keleş, E, Alpay, HC et al. Comparison of the histologic changes in conchae induced by radiofrequency thermal ablation and submucosal diathermy. Arch Otolaryngol Head Neck Surg 2013;270:2901–7Google ScholarPubMed
33Zborayova, K, Ryska, A, Miroslav, L, Petr, C, Januskova, V, Vokurka, J. Histomorphologic study of nasal turbinates after treatment: a comparison of laser surgery and radiofrequency-induced thermotherapy effects in animals. Acta Otolaryngol 2008;56:1–6Google Scholar