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The effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinate

Published online by Cambridge University Press:  12 October 2015

S Sengul ,
İ Kaygusuz ,
M M Akin ,
Ş Yalcin ,
T Karlidag ,
E Keles  and
İ Arslan
S Sengul
Affiliation:
Department of Otorhinolaryngology, Government Hospital, Karabük, Turkey
İ Kaygusuz*
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
M M Akin
Affiliation:
Department of Pathology, Medical Faculty, Firat University, Elazig, Turkey
Ş Yalcin
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
T Karlidag
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
E Keles
Affiliation:
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
İ Arslan
Affiliation:
Department of Otorhinolaryngology, Government Hospital, Bingöl, Turkey
*
Address for correspondence: Prof. İ Kaygusuz, Department of Otorhinolaryngology, Firat UniversityMedical Faculty, 23200 Elazig, Turkey Fax: +90 424 238 80 96 E-mail: [email protected]
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Abstract

Objective:

This study aimed to assess the histopathological effect of OK-432 (Picibanil) on rabbit nasal turbinates.

Methods:

A total of 21 rabbits were divided into 3 treatment groups and various parts of both nasal turbinates were injected with 0.5 ml OK-432, 0.2 ml OK-432 or 0.6 ml saline (control). Bilateral nasal turbinates were later excised and studied under light microscopy to assess any histopathological changes.

Results:

Animals in the 0.2 ml and 0.5 ml OK-432 groups exhibited mild ciliary loss, goblet cell loss and epithelial damage, and a marked increase in inflammatory cell infiltration, submucosal vascularisation and fibrosis. There was a significant difference in histopathological changes between the two OK-432 treated groups. In addition, each OK-432 treated group had significantly more inflammatory cell infiltration, increased submucosal vascularisation and fibrosis compared with controls.

Conclusion:

The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size.

Keywords

TurbinatesHypertrophyNasal ObstructionPicibanil
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 12 , December 2015 , pp. 1208 - 1212
Copyright
Copyright © JLO (1984) Limited 2015 

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Footnotes

Presented as an oral poster at the 36th Turkish National Otorhinolaryngology Head and Neck Surgery Congress, 5–9 November, 2014. Antalya, Turkey

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