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Effect of nasolacrimal duct obstruction on nasal mucociliary transport

Published online by Cambridge University Press:  30 October 2009

B Naiboglu ,
I Deveci ,
C Kalaycik ,
A Daylan ,
T E Habesoglu ,
S Z Toros ,
S E Deveci  and
E Egeli
B Naiboglu*
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
I Deveci
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
C Kalaycik
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
A Daylan
Affiliation:
Ophthalmology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
T E Habesoglu
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
S Z Toros
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
S E Deveci
Affiliation:
Otolaryngology Clinic, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey
E Egeli
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
*
Address for correspondence: Dr B Naiboglu, Haydarpasa Numune Hastanesi, Tıbbiye Caddesi No 18, PK 34668 Selimiye, Uskudar, İstanbul, Turkey. Fax: 00902163360565 E-mail: [email protected]
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Abstract

Background:

Most patients with nasolacrimal duct obstruction have dry, crusty nasal mucosa. Mucociliary clearance is modulated by the amount and biochemical composition of nasal mucus. Nasolacrimal duct obstruction disturbs the drainage of tears into the nasal cavity.

Objective:

We examined the effect of nasolacrimal duct obstruction on the mucociliary transport of nasal mucosa, by comparing saccharine test results for epiphora patients versus healthy volunteers.

Study design:

Prospective, randomised, clinical trial.

Methods:

Eight patients with bilateral epiphora and 10 patients with unilateral epiphora were included in the study group. Complete nasolacrimal duct obstruction was demonstrated by studying irrigation of the nasolacrimal system, and by fluorescein dye study. The control group comprised 20 healthy volunteers. Mucociliary transport was assessed by the saccharine test in both the study and control groups. The saccharine transit times of 26 impaired nasal cavities were compared with those of 20 healthy nasal cavities of controls. Also, the saccharine transit times of the healthy nasal cavities of the 10 patients with unilateral epiphora were compared with those of their diseased sides, and also with those of healthy volunteers.

Results:

The saccharine transit times of the epiphora patients were statistically significantly greater than those of the control group. Also, there was a statistically significant difference in saccharine transit times, comparing the healthy and impaired nasal cavities of patients with unilateral epiphora.

Conclusion:

Nasolacrimal duct obstruction has a negative effect on nasal mucociliary clearance. This may be related to changes in the amount and biochemical composition of nasal mucus.

Keywords

Nasolacrimal DuctEpiphoraNasal MucosaMucociliary Transport
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 166 - 170
Copyright
Copyright © JLO (1984) Limited 2009

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