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Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study

Published online by Cambridge University Press:  26 January 2015

G Genc ,
M Koyuncu ,
G Kutlar ,
T Guvenc ,
A Gacar ,
A Aksoy ,
S Arslan  and
S C Kurnaz
G Genc*
Affiliation:
Department of Otolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey
M Koyuncu
Affiliation:
Department of Otolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey
G Kutlar
Affiliation:
Department of Otolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey
T Guvenc
Affiliation:
Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
A Gacar
Affiliation:
Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
A Aksoy
Affiliation:
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
S Arslan
Affiliation:
Department of Biometry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
S C Kurnaz
Affiliation:
Department of Otolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey
*
Address for correspondence: Dr Gunes Genc, Department of Otolaryngology, School of Medicine, Ondokuz Mayis University, 55139 Kurupelit, Samsun, Turkey E-mail: [email protected]
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Abstract

Objective:

To demonstrate the inhibitory effects of clarithromycin on in vitro tympanosclerosis.

Method:

Twenty-eight rats were divided into three groups: a clarithromycin group, a non-clarithromycin group and a negative control group. Those in the first two groups were injected with Streptococcus pneumoniae following a myringotomy, and tympanosclerosis was experimentally induced. Oral clarithromycin therapy was administered in the clarithromycin group. The other groups received no medical treatment.

Results:

All eardrums in the clarithromycin and non-clarithromycin groups developed myringosclerosis, but there was only one eardrum, in the clarithromycin group, with very severe myringosclerosis. In the clarithromycin group, 11 ears showed no inflammation and there were no ears with severe inflammation. In the non-clarithromycin group, there were 11 ears with severe inflammation. The mean eardrum thickness in the clarithromycin group was 20.93 µm and in the non-clarithromycin group it was 42.71 µm.

Conclusion:

Acute otitis media and myringotomies induced tympanosclerosis, but clarithromycin reduced the severity of tympanosclerosis.

Keywords

TympanosclerosisClarithromycinMiddle EarOtitis Media
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 2 , February 2015 , pp. 136 - 141
Copyright
Copyright © JLO (1984) Limited 2015 

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