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DNA flow cytometry of acinic cell carcinomas of major salivary glands

Published online by Cambridge University Press:  29 June 2007

Adel K. El-Naggar ,
J. G. Batsakis ,
Mario A. Luna ,
Donia McLemore  and
R. M. Byers
Adel K. El-Naggar
Affiliation:
Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
J. G. Batsakis*
Affiliation:
Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mario A. Luna
Affiliation:
Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Donia McLemore
Affiliation:
Departments of Veterinary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
R. M. Byers
Affiliation:
Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
*
Dr J. G. Batsakis, M.D., Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
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Abstract

Fifteen acinic cell carcinomas from an equal number of patients were analysed for their DNA content and proliferative (S-phase) index by flow cytometry from archival tissues. Seven of the carcinomas manifested a diploid DNA content. None of the patients with diploid acinic cell carcinomas died of their carcinomas and none developed metastases in follow-up periods extending for 10 or more years. Four of eight patients with aneuploid acinic cell carcinomas have died because of their malignancies within a 10 year period after the first surgical removal of the carcinoma. Five of the eight patients exhibited metastases. Although the number of cases does not permit strong correlations between histopathological features, abnormalities in DNA content and outcome of patients, it was noted that carcinomas with prominent necrosis, tubulo ductal differentiation and ‘dedifferentiated’ areas displayed more aggressive biological courses.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 5 , May 1990 , pp. 410 - 416
Copyright
Copyright © JLO (1984) Limited 1990

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