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Differential diagnosis of pleomorphic adenoma by immunohistochemical means

Published online by Cambridge University Press:  29 June 2007

Toshiro Nishimura ,
Mitsuru Furukawa ,
Ei Kawahara  and
Atsuo Miwa
Toshiro Nishimura*
Affiliation:
Departments of Otolaryngology, School of Medicine, Kanazawa University
Mitsuru Furukawa
Affiliation:
Departments of Otolaryngology, School of Medicine, Kanazawa University
Ei Kawahara
Affiliation:
Departments of Pathology, School of Medicine, Kanazawa University
Atsuo Miwa
Affiliation:
Section of Pathology, Toyama Central Prefectural Hospital.
*
Toshiro Nishimura, M.D., Department of Otolaryngology, Suzu City General Hospital, lidamachi 5–9, Suzu 927–12, Ishikawa, Japan.
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Abstract

Immunohistochemical study of major salivary gland tumours was performed on 60 pleomorphic adenomas, five basal cell adenomas and 10 adenoid cystic carcinomas to determine the diagnostic value of each antigen. Immunoreactivity examined were intermediate filaments (keratin, vimentin, desmin and glial fibrillary acidic protein [GFAP]) and related substances (actin, S-100 protein and secretory component). In pleomorphic adenomas, there was positive immunoreactivity for GFAP which was not observed in normal tissue or other neoplastic tissues. Immunoreactivity of GFAP was closely related to myxomatous and early chondromatous differentiation in pleomorphic adenoma. It is considered that GFAP immunoreactivity should be assessed in the occasional differential diagnostic dilemma of pleomorphic adenoma versus adenoid cystic carcinoma and basal cell adenoma, because of its ability to show potential and definite myxochondromatous differentiation.

Keywords

Pleomorphic adenomaImmunohistochemistryGlial fibrillary acidic proteinSalivary gland neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 12 , December 1991 , pp. 1057 - 1060
Copyright
Copyright © JLO (1984) Limited 1991

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References

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