Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-28T19:45:18.714Z Has data issue: false hasContentIssue false
  • English
  • Français

Diagnostic imaging of the larynx: autofluorescence of laryngeal tumours using the helium-cadmium laser

Published online by Cambridge University Press:  29 June 2007

Meredydd Lloyd Harries ,
Stephen Lam ,
Calum MacAulay ,
Jianan Qu  and
Branko Palcic
Meredydd Lloyd Harries*
Affiliation:
Fellow in Phonosurgery, Vancouver General Hospital.
Stephen Lam
Affiliation:
British Columbia Cancer Agency, Vancouver, Canada.
Calum MacAulay
Affiliation:
British Columbia Cancer Agency, Vancouver, Canada.
Jianan Qu
Affiliation:
British Columbia Cancer Agency, Vancouver, Canada.
Branko Palcic
Affiliation:
British Columbia Cancer Agency, Vancouver, Canada.
*
Address for correspondence: Mr M. L. Harries, The Voice Clinic, Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London WCIX 8DA.
Get access Rights & Permissions [Opens in a new window]

Abstract

The use of tissue autofluorescence for the detection and localization of cancer of the larynx is described. In this pilot study, eight patients with probable carcinoma of the vocal folds underwent laryngoscopy in which the tissue autofluorescence spectra of normal and pathologically confirmed tumour tissue were acquired in vivo. Fluorescence images of the suspect areas were also acquired using the LIFE system (Xillix Technologies Corp.). The results suggest that the autofluorescence properties of laryngeal tissue, under 442 nm illumination, are similar to those of bronchial tissue and that the LIFE system has the potential to increase the accuracy of staging of cancer of the larynx and also to allow earlier diagnosis of tumours and theirrecurrence

Keywords

Laryngeal neoplasmsLasers
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 2 , February 1995 , pp. 108 - 110
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Belliner, O., Doiron, D. R., Huth, G. (1984) HPD photodynamic therapy for obstructing lung cancer: porphyrin localization and treatment of tumors, Alan R. Liss, New York, pp 727–745.Google Scholar
Ghisla, S., Massey, V., Lhoste, J.-M., Mayhew, S. S. (1975) Fluorescence characteristics of reduced flavins and flavoproteins. In Reactivity of Flavins. (Yagi, K., ed.), University of Tokyo Press, Tokyo; pp 15–24.Google Scholar
Gluckman, J. (1991a) Photodynamic therapy for head and neck neoplasms. Otolaryngologic Clinics of North America 24: 1559–1567.CrossRefGoogle ScholarPubMed
Gluckman, J. (1991b) Haematoporphyrin photodynamic therapy – is there truly a future in head and neck oncology? Reflections on a 5-year experience. Laryngoscope 101: 36–41.CrossRefGoogle ScholarPubMed
Hung, J., Lam, S., LeRiche, J. J. (1991) Autofluorescence of normal and malignant bronchial tissue. Lasers in Surgery and Medicine 11: 99–105.CrossRefGoogle ScholarPubMed
Lam, S., Hung, J., Palcic, B. (1991) Mechanism of detection of early lung cancer by ratio fluorometry. Lasers LIFE Science 4: 67–73.Google Scholar
Lam, S., MacAulay, C., Hung, J. (1993) Detection of dysplasia and carcinoma in situ using a lung imaging fluorescence endoscope (LIFE) device. Journal of Thoracic and Cardiovascular Surgery 105: 1035–1040.CrossRefGoogle Scholar
Palcic, B., Lam, S., Hung, J., MacAulay, C. (1991) Detection and localization of early lung cancer by imaging techniques. Chest 99:742–743.CrossRefGoogle ScholarPubMed
Pollack, M. (1942) B vitamins in cancerous tissues. I: Riboflavin. Cancer Research 99(2): 739–743.Google Scholar
Qu, J., MacAulay, C., Lam, S., Palcic, B. (1994) Optical properties of normal and carcinoma bronchial tissue. Applied Optics (in press).CrossRefGoogle Scholar