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Diagnosis and treatment of necrotising otitis externa and diabetic foot osteomyelitis – similarities and differences

Published online by Cambridge University Press:  28 August 2018

C Peled*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University in the Negev, Beer-Sheva, Israel
M Kraus
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University in the Negev, Beer-Sheva, Israel
D Kaplan
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University in the Negev, Beer-Sheva, Israel
*
Author for correspondence: Dr Chilaf Peled, Department of Otolaryngology – Head and Neck Surgery, Soroka, University Medical Center, POB 151, Beer-Sheva, Israel E-mail: [email protected]

Abstract

Objective

Necrotising otitis externa is a severe inflammatory process affecting soft tissue and bone, mostly in diabetic patients. Diabetic patients are also at risk of diabetic foot osteomyelitis, another inflammatory condition involving soft tissue and bone. This review aimed to describe the similarities and differences of these entities in an attempt to further advance the management of necrotising otitis externa.

Method

A PubMed search was conducted using the key words ‘otitis externa’, ‘necrotising otitis externa’, ‘malignant otitis externa’, ‘osteomyelitis’ and ‘diabetic foot’.

Results and conclusion

The similarities regarding patient population and pathophysiology between necrotising otitis externa and diabetic foot osteomyelitis raise basic questions concerning the effects of long-standing diabetes on the external ear. The concordance between local swabs and bone cultures in diabetic foot osteomyelitis is less than 50 per cent. If this holds true also to necrotising otitis externa, the role of deep tissue cultures should be strongly considered. Similar to diabetic foot osteomyelitis, magnetic resonance imaging should be considered in selected necrotising otitis externa subgroups.

Type
Review Articles
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr C Peled takes responsibility for the integrity of the content of the paper

References

1Chandler, JR. Malignant external otitis. Laryngoscope 1968;78:1257–94Google Scholar
2Abbott, CA, Carrington, AL, Ashe, H, Bath, S, Every, LC, Griffiths, J et al. The North-West Diabetes Foot Study: incidence of, and risk factors for, new diabetic foot ulcer in a community-based patient cohort. Diabet Med 2002;19:377–84Google Scholar
3Lavery, LA, Peters, EJ, Armstrong, DG, Wendel, CS, Murdoch, DP, Lipsky, BA. Risk factors for developing osteomyelitis in patients with diabetic foot wounds. Diabetes Res Clin Pract 2009;83:347–52Google Scholar
4Stroman, D, Roland, P, Dohar, J, Burt, W. Microbiology of normal external auditory canal. Laryngoscope 2001;111:2054–9Google Scholar
5Rubin, J, Yu, VL. Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnosis and therapy. Am J Med 1988;85:391–8Google Scholar
6Mahdyoun, P, Pulcini, C, Gahide, I, Raffaelli, C, Savoldelli, C, Castillo, L et al. Necrotizing otitis externa: a systematic review. Otol Neurotol 2013;34:620–9Google Scholar
7Bayardelle, P, Jolivet-Granger, M, Larochelle, D. Staphylococcal malignant otitis externa. Can Med Assoc J 1982;126:155–6Google Scholar
8Garcia Rodriguez, JA, Montes Martinez, I, Gómez González, JL, Ramos Macias, A, Lopez Alburquerque, T. A case of malignant external otitis involving Klebsiella oxytoca. Eur J Clin Microbiol Infect Dis 1992;11:75–7Google Scholar
9Barrow, HN, Levenson, MJ. Necrotising “malignant” external otitis caused by Staphylococcal epidermidis. Arch Otolaryngol Head Neck Surg 1992;118:94–6Google Scholar
10Hollis, S, Evans, K. Management of malignant (necrotising) otitis externa. J Laryngol Otol 2011;125:1212–17Google Scholar
11Bae, WK, Lee, KS, Park, JW, Bae, EH, Ma, SK, Kim, NH et al. A case of malignant otitis externa caused by Candida glabrata in a patient receiving haemodialysis. Scand J Infect Dis 2007;39:370–2Google Scholar
12Gruber, M, Roitman, A, Doweck, I, Uri, N, Shaked-Mishan, P, Kolop-Feldman, A et al. Clinical utility of a polymerase chain reaction assay in culture-negative necrotizing otitis externa. Otol Neurotol 2015;36:733–6Google Scholar
13Lipsky, BA, Berendt, AR, Cornia, PB, Pile, JC, Peters, EJ, Armstrong, DG et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2012;54:132–73Google Scholar
14Yener, S, Topcu, A, Manisali, M, Comlekci, A, Yesil, S. Candida albicans osteomyelitis in a diabetic foot ulcer. J Diabetes Complications 2009;23:137–9Google Scholar
15Lew, DP, Waldvogel, FA. Osteomyelitis. Lancet 2004;364:369–79Google Scholar
16Game, FL. Osteomyelitis in the diabetic foot diagnosis and management. Med Clin North Am 2013;97:947–56Google Scholar
17Peleg, U, Perez, R, Raveh, D, Berelowitz, D, Cohen, D. Stratification for malignant otitis externa. Otolaryngol Head Neck Surg 2007;137:301–5Google Scholar
18Okpala, NC, Siraj, QH, Nilssen, E, Pringle, M. Radiological and radionuclide investigation of malignant otitis externa. J Laryngol Otol 2005;119:71–5Google Scholar
19Game, FL, Jeffcoate, WJ. Primarily non-surgical management of osteomyelitis of the foot in diabetes. Diabetologia 2008;51:962–7Google Scholar
20Pineda, C, Espinosa, R, Pena, A. Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging, and scintigraphy. Semin Plast Surg 2009;23:80–9Google Scholar
21Dinh, MT, Abad, CL, Safdar, N. Diagnostic accuracy of the physical examination and imaging tests for osteomyelitis underlying diabetic foot ulcers: meta-analysis. Clin Infect Dis 2008;47:519–27Google Scholar
22Tomas, MB, Patel, M, Marwin, SE, Palestro, CJ. The diabetic foot. Br J Radiol 2000;73:443–50Google Scholar
23Loh, S, Loh, WS. Malignant otitis externa: an Asian perspective on treatment outcomes and prognostic factors. Otolaryngol Head Neck Surg 2012;148:991–6Google Scholar
24Peters, E, Lipsky, BA. Diagnosis and management of infection in the diabetic foot. Med Clin North Am 2013;97:911–46Google Scholar
25Karaman, E, Yilmaz, M, Ibrahimov, M, Haciyev, Y, Enver, O. Malignant otitis externa. J Craniofac Surg 2012;23:1748–51Google Scholar
26Marais, LC, Ferreira, N, Aldous, C, Sartorius, B, Le Roux, T. A modified staging system for chronic osteomyelitis. J Orthop 2015;12:184–92Google Scholar
27Stevens, SM, Lambert, PR, Baker, AB, Mayer, TA. Malignant otitis externa: a novel stratification protocol for predicting treatment outcomes. Otol Neurotol 2015;36:1492–8Google Scholar
28Carfrea, MJ, Kesser, BW. Malignant otitis externa. Otolaryngol Clin North Am 2008;41:537–49Google Scholar
29Davis, WA, Norman, PE, Bruce, DG, Davis, TM. Predictors, consequences and costs of diabetes-related lower extremity amputation complicating type 2 diabetes: the Fremantle Diabetes Study. Diabetologia 2006;49:2634–41Google Scholar
30Grandis, JR, Branstetter, BF, Yu, VL. The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004;4:34–9Google Scholar
31Chen, YH, Hsieh, HJ. Single photon emission computed tomography/computed tomography for malignant otitis externa: lesion not shown on planar image. Am J Otolaryngol 2013;34:169–71Google Scholar