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Cyclin Dl expression as a prognostic factor in advanced hypopharyngeal carcinoma

Published online by Cambridge University Press:  29 June 2007

Goshi Nishimura ,
Mamoru Tsukuda ,
Li-Xin Zhou ,
Shigeru Furukawa  and
Yuh Baba
Goshi Nishimura*
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Mamoru Tsukuda
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Li-Xin Zhou
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Shigeru Furukawa
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Yuh Baba
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
*
AddressAddress for correspondence: Goshi Nishimura, M.D., Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan236-0004.
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Abstract

Hypopharyngeal carcinoma (HPC) has a poor prognosis. We investigated the expression of cyclin D1 in 34 advanced HPCs, and the value of cyclin D1 expression was evaluated as a predictive marker in terms of the prognosis of HPC, compared with other clinical factors. Using immunohistochemical staining, 20 of 34 patients showed positive immunoreactivity for cyclin D1. The statistical trend of the survival rate was lower in the cyclin Di-positive patients than in the cyclin D-negative ones (p = 0.0805). The predictive factors for the survival rate were effectiveness of neo-adjuvant chemotherapy (F = 8.698) (p = 0.0066), cyclin D1 expression (F = 6.244) (p = 0.0191) and N classification (F = 5.037) (p = 0.0335). The cyclin D1-positive patients had approximately four-fold higher mortality than the cyclin D1-negative ones. These data indicate that the expression of cyclin D1 in advanced patients with hypopharyngeal carcinoma is a useful marker for prognosis.

Keywords

HypopharynxCarcinomaImmunochemistryPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 6 , June 1998 , pp. 552 - 555
Copyright
Copyright © JLO (1984) Limited 1998

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