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Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure

Published online by Cambridge University Press:  11 June 2019

N Choi ,
J S Kim  and
Y-S Chang
N Choi
Affiliation:
Department of Otorhinolaryngology, Republic of Korea Armed Forces Capital Hospital, Bundang, Republic of Korea
J S Kim
Affiliation:
28th Regiment, 9th Division, Republic of Korea Armed Forces, Goyang, Republic of Korea
Y-S Chang*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Korea University College of Medicine, Korea University Ansan Hospital, Ansan-si, Republic of Korea
*
Author for correspondence: Dr Young-Soo Chang, Department of Otorhinolaryngology – Head and Neck Surgery, Korea University College of Medicine, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Republic of Korea15355 E-mail: [email protected]
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Abstract

Background

There are no definite guidelines regarding the most adequate steroid regimens for acute acoustic trauma.

Objective

To elucidate the dose-dependent differing benefits of oral steroids on hearing improvement following acute acoustic trauma.

Methods

Twenty-nine patients treated with oral steroids following a diagnosis of unilateral acute acoustic trauma were retrospectively reviewed. Patients were sorted into two groups with an oral steroid regimen. Group 1 received a 14-day course of treatment: 60 mg prednisolone daily for 10 days, tapering off over days 11–14. Group 2 received prednisolone for a total of 10 days: 60 mg for 5 days, tapering down each day for the remainder. Multivariable linear regression analysis was performed to evaluate the factors associated with the hearing gain.

Results

In the multivariable regression (R2 = 0.51, p < 0.001), patients in group 1 showed more significant improvement in the degree of hearing gain compared to group 2 (p = 0.03).

Conclusion

After comparing the differing benefits of oral steroids on hearing improvement by dosage, we recommend a high dose of prednisolone (60 mg per day) for 10 days, tapering over the remaining 4 days, for better hearing recovery following acute acoustic trauma.

Keywords

Hearing Loss, Noise-InducedAcoustic TraumaSteroidsOral Drug AdministrationPrednisolone
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 7 , July 2019 , pp. 566 - 570
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr Y-S Chang takes responsibility for the integrity of the content of the paper

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