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Comparison of nasal cytology and symptom scores in patients with seasonal allergic rhinitis, before and after treatment

Published online by Cambridge University Press:  27 July 2011

A Özgür ,
S Arslanoğlu ,
D Etıt ,
U Demıray  and
H K Önal
A Özgür
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
S Arslanoğlu*
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
D Etıt
Affiliation:
Department of Pathology, İzmir Atatürk Training and Research Hospital, Turkey
U Demıray
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
H K Önal
Affiliation:
Department of Otorhinolaryngology, İzmir Atatürk Training and Research Hospital, Turkey
*
Address for correspondence: Dr Seçil Arslanoğlu, İnönü Cad No 556/3, 35290 İzmir, Turkey Fax:  +90232 243 15 30 E-mail: [email protected]
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Abstract

Objective:

To evaluate symptom scores and nasal smear cytology findings in seasonal allergic rhinitis patients, before and after treatment.

Methods:

Twenty-nine consecutive adult patients with seasonal allergic rhinitis were evaluated prospectively. They received mometasone furoate nasal spray and cetirizine for 21 days. Nasal and ocular symptom scores were recorded before and after treatment. Nasal cytology was also assessed as a means of determining treatment.

Results:

The combined use of an intranasal corticosteroid and an oral antihistamine caused a significant improvement in nasal and ocular symptom scores. Cytological evaluation revealed significant reduction in nasal eosinophil, neutrophil and goblet cell counts after three weeks' treatment.

Conclusion:

Symptom scoring systems are widely used for the evaluation of drug efficacy in allergic rhinitis treatment. When investigating the disease and evaluating treatment efficacy, objective as well as subjective methods are needed. Nasal cytological assessment is a simple, objective method which provides valuable information about the nasal mucosa.

Keywords

RhinitisPathologyCell BiologySymptoms And Signs
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 10 , October 2011 , pp. 1028 - 1032
Copyright
Copyright © JLO (1984) Limited 2011

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